Gene Review:
RAD53 - Rad53p
Saccharomyces cerevisiae S288c
Synonyms:
CHEK2 homolog, LSD1, MEC2, P2588, SAD1, ...
- Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae. Pike, B.L., Yongkiettrakul, S., Tsai, M.D., Heierhorst, J. Mol. Cell. Biol. (2004)
- A Rad53 kinase-dependent surveillance mechanism that regulates histone protein levels in S. cerevisiae. Gunjan, A., Verreault, A. Cell (2003)
- Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions. Corda, Y., Schramke, V., Longhese, M.P., Smokvina, T., Paciotti, V., Brevet, V., Gilson, E., Géli, V. Nat. Genet. (1999)
- The DNA replication checkpoint response stabilizes stalled replication forks. Lopes, M., Cotta-Ramusino, C., Pellicioli, A., Liberi, G., Plevani, P., Muzi-Falconi, M., Newlon, C.S., Foiani, M. Nature (2001)
- Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. Woolstencroft, R.N., Beilharz, T.H., Cook, M.A., Preiss, T., Durocher, D., Tyers, M. J. Cell. Sci. (2006)
- Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B., Elledge, S.J. Science (1996)
- Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Desany, B.A., Alcasabas, A.A., Bachant, J.B., Elledge, S.J. Genes Dev. (1998)
- Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. Sidorova, J.M., Breeden, L.L. Genes Dev. (1997)
- MEC1-dependent phosphorylation of Rad9p in response to DNA damage. Emili, A. Mol. Cell (1998)
- A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Zhao, X., Muller, E.G., Rothstein, R. Mol. Cell (1998)
- SUN1 Interacts with Nuclear Lamin A and Cytoplasmic Nesprins To Provide a Physical Connection between the Nuclear Lamina and the Cytoskeleton. Haque, F., Lloyd, D.J., Smallwood, D.T., Dent, C.L., Shanahan, C.M., Fry, A.M., Trembath, R.C., Shackleton, S. Mol. Cell. Biol. (2006)
- Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Sun, Z., Fay, D.S., Marini, F., Foiani, M., Stern, D.F. Genes Dev. (1996)
- A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation. Lee, S.J., Duong, J.K., Stern, D.F. Mol. Biol. Cell (2004)
- SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase. Zheng, P., Fay, D.S., Burton, J., Xiao, H., Pinkham, J.L., Stern, D.F. Mol. Cell. Biol. (1993)
- Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling. Lee, S.J., Schwartz, M.F., Duong, J.K., Stern, D.F. Mol. Cell. Biol. (2003)
- Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Sun, Z., Hsiao, J., Fay, D.S., Stern, D.F. Science (1998)
- Interferon-gamma activation of a mitogen-activated protein kinase, KFR1, in the bloodstream form of Trypanosoma brucei. Hua, S.B., Wang, C.C. J. Biol. Chem. (1997)
- Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway. Sugimoto, K., Ando, S., Shimomura, T., Matsumoto, K. Mol. Cell. Biol. (1997)
- The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Allen, J.B., Zhou, Z., Siede, W., Friedberg, E.C., Elledge, S.J. Genes Dev. (1994)
- Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways. Shimomura, T., Ando, S., Matsumoto, K., Sugimoto, K. Mol. Cell. Biol. (1998)
- Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53. Tourrière, H., Versini, G., Cordón-Preciado, V., Alabert, C., Pasero, P. Mol. Cell (2005)
- Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. O'Neill, B.M., Szyjka, S.J., Lis, E.T., Bailey, A.O., Yates, J.R., Aparicio, O.M., Romesberg, F.E. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1. Chen, S.H., Zhou, H. J. Biol. Chem. (2009)
- RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. Navas, T.A., Sanchez, Y., Elledge, S.J. Genes Dev. (1996)
- The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression. Searle, J.S., Schollaert, K.L., Wilkins, B.J., Sanchez, Y. Nat. Cell Biol. (2004)
- RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation. de la Torre-Ruiz, M.A., Green, C.M., Lowndes, N.F. EMBO J. (1998)
- Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae. Marsolier, M.C., Roussel, P., Leroy, C., Mann, C. Genetics (2000)
- Regulation of DNA-replication origins during cell-cycle progression. Shirahige, K., Hori, Y., Shiraishi, K., Yamashita, M., Takahashi, K., Obuse, C., Tsurimoto, T., Yoshikawa, H. Nature (1998)
- Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Cotta-Ramusino, C., Fachinetti, D., Lucca, C., Doksani, Y., Lopes, M., Sogo, J., Foiani, M. Mol. Cell (2005)