Gene Review:
RAD52 - recombinase RAD52
Saccharomyces cerevisiae S288c
Synonyms:
DNA repair and recombination protein RAD52, YML032C
- Induction of mitotic crossing-over by the topoisomerase II poison DACA (N-[2-dimethylamino)ethyl]acridine-4-carboxamide) in Saccharomyces cerevisiae. Ferguson, L.R., Turner, P.M., Baguley, B.C. Mutat. Res. (1993)
- Yeast gene RAD52 can substitute for phage T4 gene 46 or 47 in carrying out recombination and DNA repair. Chen, D.S., Bernstein, H. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells. Fujimori, A., Tachiiri, S., Sonoda, E., Thompson, L.H., Dhar, P.K., Hiraoka, M., Takeda, S., Zhang, Y., Reth, M., Takata, M. EMBO J. (2001)
- The human Rad52 protein exists as a heptameric ring. Stasiak, A.Z., Larquet, E., Stasiak, A., Müller, S., Engel, A., Van Dyck, E., West, S.C., Egelman, E.H. Curr. Biol. (2000)
- INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Morrison, A.J., Highland, J., Krogan, N.J., Arbel-Eden, A., Greenblatt, J.F., Haber, J.E., Shen, X. Cell (2004)
- Telomere dysfunction increases mutation rate and genomic instability. Hackett, J.A., Feldser, D.M., Greider, C.W. Cell (2001)
- A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Tishkoff, D.X., Filosi, N., Gaida, G.M., Kolodner, R.D. Cell (1997)
- Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Essers, J., Hendriks, R.W., Swagemakers, S.M., Troelstra, C., de Wit, J., Bootsma, D., Hoeijmakers, J.H., Kanaar, R. Cell (1997)
- Construction of a mouse yeast artificial chromosome library in a recombination-deficient strain of yeast. Chartier, F.L., Keer, J.T., Sutcliffe, M.J., Henriques, D.A., Mileham, P., Brown, S.D. Nat. Genet. (1992)
- DNA structure-dependent requirements for yeast RAD genes in gene conversion. Sugawara, N., Ivanov, E.L., Fishman-Lobell, J., Ray, B.L., Wu, X., Haber, J.E. Nature (1995)
- Synergistic actions of Rad51 and Rad52 in recombination and DNA repair. Benson, F.E., Baumann, P., West, S.C. Nature (1998)
- A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae. Bai, Y., Symington, L.S. Genes Dev. (1996)
- Recombinational repair in yeast: functional interactions between Rad51 and Rad54 proteins. Clever, B., Interthal, H., Schmuckli-Maurer, J., King, J., Sigrist, M., Heyer, W.D. EMBO J. (1997)
- Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break. Signon, L., Malkova, A., Naylor, M.L., Klein, H., Haber, J.E. Mol. Cell. Biol. (2001)
- MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae. Hryciw, T., Tang, M., Fontanie, T., Xiao, W. Mol. Genet. Genomics (2002)
- Yeast cell-free system that catalyses joint-molecule formation in a Rad51p- and Rad52p-dependent fashion. Nagaraj, V., Norris, D. Biochem. J. (2000)
- Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52. Yamaguchi-Iwai, Y., Sonoda, E., Buerstedde, J.M., Bezzubova, O., Morrison, C., Takata, M., Shinohara, A., Takeda, S. Mol. Cell. Biol. (1998)
- The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues. Shen, Z., Denison, K., Lobb, R., Gatewood, J.M., Chen, D.J. Genomics (1995)
- Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52 in Saccharomyces cerevisiae. Onoda, F., Seki, M., Miyajima, A., Enomoto, T. Mol. Gen. Genet. (2001)
- Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae. O'Brien, T.J., Fornsaglio, J.L., Ceryak, S., Patierno, S.R. DNA Repair (Amst.) (2002)
- Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae. Haracska, L., Torres-Ramos, C.A., Johnson, R.E., Prakash, S., Prakash, L. Mol. Cell. Biol. (2004)
- The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast. McA'Nulty, M.M., Lippard, S.J. Mutat. Res. (1996)
- Transcriptional regulation of DNA damage responsive (DDR) genes in different rad mutant strains of Saccharomyces cerevisiae. Maga, J.A., McClanahan, T.A., McEntee, K. Mol. Gen. Genet. (1986)
- Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A. New, J.H., Sugiyama, T., Zaitseva, E., Kowalczykowski, S.C. Nature (1998)
- The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing. Davis, A.P., Symington, L.S. Genetics (2001)
- Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes. Gasior, S.L., Wong, A.K., Kora, Y., Shinohara, A., Bishop, D.K. Genes Dev. (1998)
- Telomere formation by rap1p binding site arrays reveals end-specific length regulation requirements and active telomeric recombination. Grossi, S., Bianchi, A., Damay, P., Shore, D. Mol. Cell. Biol. (2001)
- Further characterization of the yeast pso4-1 mutant: interaction with rad51 and rad52 mutants after photoinduced psoralen lesions. de Morais, M.A., Vicente, E.J., Brozmanova, J., Schenberg, A.C., Henriques, J.A. Curr. Genet. (1996)
- The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus. Torres-Rosell, J., Sunjevaric, I., De Piccoli, G., Sacher, M., Eckert-Boulet, N., Reid, R., Jentsch, S., Rothstein, R., Aragón, L., Lisby, M. Nat. Cell Biol. (2007)
- Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage. Liu, Y., Li, M., Lee, E.Y., Maizels, N. Curr. Biol. (1999)
- The effect of a suppressed rad52 mutation on the suppression of rad6 by srs2. Nguyen, M.M., Livingston, D.M. Yeast (1997)
- An allele of RFA1 suppresses RAD52-dependent double-strand break repair in Saccharomyces cerevisiae. Smith, J., Rothstein, R. Genetics (1999)
- In-vitro recombination in rad and rnc mutants of Saccharomyces cerevisiae. Moore, P.D., Simon, J.R., Wallace, L.J., Chow, T.Y. Curr. Genet. (1993)
- Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins. Hays, S.L., Firmenich, A.A., Berg, P. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein rfa1 in Saccharomyces cerevisiae. Erdeniz, N., Rothstein, R. Mol. Cell. Biol. (2000)
- Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events. Chen, Q., Ijpma, A., Greider, C.W. Mol. Cell. Biol. (2001)
- DNA length dependence of the single-strand annealing pathway and the role of Saccharomyces cerevisiae RAD59 in double-strand break repair. Sugawara, N., Ira, G., Haber, J.E. Mol. Cell. Biol. (2000)
- Requirement of RAD52 group genes for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae. Gangavarapu, V., Prakash, S., Prakash, L. Mol. Cell. Biol. (2007)
- Rad51 protein controls Rad52-mediated DNA annealing. Wu, Y., Kantake, N., Sugiyama, T., Kowalczykowski, S.C. J. Biol. Chem. (2008)
- Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway. Huang, M.E., Rio, A.G., Galibert, M.D., Galibert, F. Genetics (2002)
- Direction of chromosome rearrangements in Saccharomyces cerevisiae by use of his3 recombinational substrates. Fasullo, M.T., Davis, R.W. Mol. Cell. Biol. (1988)
- Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52. Chen, F., Nastasi, A., Shen, Z., Brenneman, M., Crissman, H., Chen, D.J. Mutat. Res. (1997)
- The ability of Sgs1 to interact with DNA topoisomerase III is essential for damage-induced recombination. Ui, A., Seki, M., Ogiwara, H., Onodera, R., Fukushige, S., Onoda, F., Enomoto, T. DNA Repair (Amst.) (2005)