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Gene Review

LSP1  -  Lsp1p

Saccharomyces cerevisiae S288c

Synonyms: Sphingolipid long chain base-responsive protein LSP1, YPL004C
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High impact information on LSP1

  • Pil1p and Lsp1p are thus the first proteins identified as regulators of Pkh1/2p [1].
  • Homologs of Pil1p and Lsp1p are widespread in nature, and our results suggest that they may be negative regulators of PDK-like protein kinases and their downstream cellular pathways that control cell growth and survival [1].
  • These proteins include Pil1p and Lsp1p, two sphingolipid long-chain base-responsive inhibitors of protein kinases involved in signaling pathways for cell wall integrity and Rho1p, a small GTPase [2].

Anatomical context of LSP1


  1. Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. Zhang, X., Lester, R.L., Dickson, R.C. J. Biol. Chem. (2004) [Pubmed]
  2. The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor. Delom, F., Szponarski, W., Sommerer, N., Boyer, J.C., Bruneau, J.M., Rossignol, M., Gibrat, R. Proteomics (2006) [Pubmed]
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