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Gene Review:

PIL1 - Pil1p

Saccharomyces cerevisiae S288c

Synonyms: Sphingolipid long chain base-responsive protein PIL1, YGR086C

Delom, F. et al., Zhang, X. et al., Walther, T.C. et al., Basmaji, F. et al.

Walther, Brickner, Aguilar, Bernales, Pantoja, Walter,

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High impact information on PIL1

Homologs of Pil1p and Lsp1p are widespread in nature, and our results suggest that they may be negative regulators of PDK-like protein kinases and their downstream cellular pathways that control cell growth and survival [1].
A first group consisted of Slt2 and Pil1, two proteins dedicated to cell wall maintenance and biogenesis [2].
These proteins include Pil1p and Lsp1p, two sphingolipid long-chain base-responsive inhibitors of protein kinases involved in signaling pathways for cell wall integrity and Rho1p, a small GTPase [3].
Loss of Pil1 leads to clustering of eisosome remnants and redirects endocytosis and endocytic effector proteins to these clusters [4].

Anatomical context of PIL1

It was recently hypothesized that Pil1p and Lsp1p could associate with, and regulate, the plasma membrane beta-1-3-glucan synthase, responsible for the synthesis of another major microfibril for yeast cell wall [3].

References

Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. Zhang, X., Lester, R.L., Dickson, R.C. J. Biol. Chem. (2004) [Pubmed]
The 'interactome' of the Knr4/Smi1, a protein implicated in coordinating cell wall synthesis with bud emergence in Saccharomyces cerevisiae. Basmaji, F., Martin-Yken, H., Durand, F., Dagkessamanskaia, A., Pichereaux, C., Rossignol, M., Francois, J. Mol. Genet. Genomics (2006) [Pubmed]
The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor. Delom, F., Szponarski, W., Sommerer, N., Boyer, J.C., Bruneau, J.M., Rossignol, M., Gibrat, R. Proteomics (2006) [Pubmed]
Eisosomes mark static sites of endocytosis. Walther, T.C., Brickner, J.H., Aguilar, P.S., Bernales, S., Pantoja, C., Walter, P. Nature (2006) [Pubmed]

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AGOS_AEL329W	Ashbya gossypii ATCC 10895
KLLA0F08162g	Kluyveromyces lactis NRRL Y-1140
MGG_00153	Magnaporthe oryzae 70-15
NCU07495	Neurospora crassa OR74A
SPCC736.15	Schizosaccharomyces pombe 972h-

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