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Gene Review:

CIT3 - citrate (Si)-synthase CIT3

Saccharomyces cerevisiae S288c

Synonyms: Citrate synthase 3, YP9723.01, YPR001W

Jia, Y.K. et al., Lee, J.G. et al.

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Disease relevance of CIT3

Complementation of a citrate synthase-deficient strain of Escherichia coli by lacZ::CIT3 gene fusions demonstrated that the CIT3 gene encodes an active citrate synthase [1].

High impact information on CIT3

The CIT3 gene seems to be regulated in the same way as CIT1, which encodes the mitochondrial isoform of citrate synthase [1].
In vitro import experiments showed that cit3p is transported into the mitochondria [1].

Anatomical context of CIT3

Saccharomyces cerevisiae has three distinct citrate synthases, two located in mitochondria (mature Cit1p and Cit3p) and one in peroxisomes (mature Cit2p) [2].

References

The CIT3 gene of Saccharomyces cerevisiae encodes a second mitochondrial isoform of citrate synthase. Jia, Y.K., Bécam, A.M., Herbert, C.J. Mol. Microbiol. (1997) [Pubmed]
Identification of a cryptic N-terminal signal in Saccharomyces cerevisiae peroxisomal citrate synthase that functions in both peroxisomal and mitochondrial targeting. Lee, J.G., Cho, S.P., Lee, H.S., Lee, C.H., Bae, K.S., Maeng, P.J. J. Biochem. (2000) [Pubmed]

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AGOS_AGR002W	Ashbya gossypii ATCC 10895
KLLA0E14235g	Kluyveromyces lactis NRRL Y-1140
MGG_02617	Magnaporthe oryzae 70-15
NCU02482	Neurospora crassa OR74A

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