The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TIP41  -  Tip41p

Saccharomyces cerevisiae S288c

Synonyms: PP2A phosphatase activator TIP41, TAP42-interacting protein 1, Type 2A phosphatase activator TIP41, YP3085.04, YPR040W
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on TIP41

  • TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway [1].
  • Here, we describe TIP41, a conserved TAP42-interacting protein involved in the regulation of SIT4 [1].
  • When TOR is inactivated by rapamycin treatment or nitrogen starvation, downstream effectors of TOR such as the serine/threonine protein kinase NPR1 and the TAP42 interacting protein TIP41 are dephosphorylated in a SIT4-dependent manner [2].
 

Biological context of TIP41

  • The phosphorylation state of NPR1 and TIP41 provides a convenient readout in yeast to assay for TOR and SIT4 activities under growth-promoting or growth-inhibitory conditions [2].
 

Regulatory relationships of TIP41

  • Effects of Tap42p inactivation and rapamycin addition could be suppressed by deletion of TIP41, which encodes a Tap42p-interacting protein [3].
 

Other interactions of TIP41

  • According to the model, excess nitrogen stimulates Tor1,2 to phosphorylate Tip41 and/or Tap42 [4].

References

  1. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Jacinto, E., Guo, B., Arndt, K.T., Schmelzle, T., Hall, M.N. Mol. Cell (2001) [Pubmed]
  2. Phosphatase Targets in TOR Signaling. Jacinto, E. Methods Mol. Biol. (2006) [Pubmed]
  3. PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p. Santhanam, A., Hartley, A., Düvel, K., Broach, J.R., Garrett, S. Eukaryotic Cell (2004) [Pubmed]
  4. Saccharomyces cerevisiae Sit4 Phosphatase Is Active Irrespective of the Nitrogen Source Provided, and Gln3 Phosphorylation Levels Become Nitrogen Source-responsive in a sit4-deleted Strain. Tate, J.J., Feller, A., Dubois, E., Cooper, T.G. J. Biol. Chem. (2006) [Pubmed]
 
WikiGenes - Universities