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TAP42  -  Tap42p

Saccharomyces cerevisiae S288c

Synonyms: Type 2A phosphatase-associated protein 42, YM9711.18, YM9973.01C, YMR028W
 
 
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High impact information on TAP42

  • Upon phosphorylation by TOR, TAP42 binds and possibly inhibits type 2A and type-2A-related phosphatases; however, the mechanism by which TOR controls nuclear events such as global repression of starvation-specific transcription is unknown [1].
  • Rapamycin-induced dephosphorylation of Ser 577, eIF2alpha phosphorylation, and induction of GCN4 all involve TAP42, a regulator of type 2A-related protein phosphatases [2].
  • Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2 [2].
  • In addition, Tap42/Sit4 and Tap42/PP2A complex formation is regulated by nutrient growth signals and the rapamycin-sensitive Tor signaling pathway [3].
  • Tap42 inactivation neither affects ribosomal protein gene expression nor blocks rapamycin-induced repression of these genes [4].
 

Biological context of TAP42

  • Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway [5].
  • Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast [6].
  • We identified an essential Saccharomyces cerevisiae protein, Tap42, that associates with Sit4, a type 2A-related protein phosphatase, and with the type 2A phosphatase catalytic subunits [3].
  • Intriguingly, the temperature-sensitivity of the las24 mutant was suppressed by either activation of Tap42/PPase or by down-regulation of the RAS/cAMP pathway [7].
  • These results suggest that Tap42p is an inhibitor of PP2A phosphatase, which in turn inhibits nuclear export of Msn2p [8].
 

Physical interactions of TAP42

  • TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway [9].
  • When Tor1,2 kinase activities are inhibited by limiting nitrogen, or rapamycin-treatment, Tap42 can no longer complex with Sit4 [10].
  • The Tap42-protein phosphatase type 2A catalytic subunit complex is required for cell cycle-dependent distribution of actin in yeast [11].
 

Regulatory relationships of TAP42

  • In Saccharomyces cerevisiae, the rapamycin-sensitive TOR kinases negatively regulate the type 2A-related phosphatase SIT4 by promoting the association of this phosphatase with the inhibitor TAP42 [9].
  • Effects of Tap42p inactivation and rapamycin addition could be suppressed by deletion of TIP41, which encodes a Tap42p-interacting protein [8].
 

Other interactions of TAP42

References

  1. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Beck, T., Hall, M.N. Nature (1999) [Pubmed]
  2. Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. Cherkasova, V.A., Hinnebusch, A.G. Genes Dev. (2003) [Pubmed]
  3. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Di Como, C.J., Arndt, K.T. Genes Dev. (1996) [Pubmed]
  4. Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast. Düvel, K., Santhanam, A., Garrett, S., Schneper, L., Broach, J.R. Mol. Cell (2003) [Pubmed]
  5. Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway. Onda, M., Inui, S., Maeda, K., Suzuki, M., Takahashi, E., Sakaguchi, N. Genomics (1997) [Pubmed]
  6. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. Jiang, Y., Broach, J.R. EMBO J. (1999) [Pubmed]
  7. LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. Araki, T., Uesono, Y., Oguchi, T., Toh-E, A. Genes Genet. Syst. (2005) [Pubmed]
  8. PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p. Santhanam, A., Hartley, A., Düvel, K., Broach, J.R., Garrett, S. Eukaryotic Cell (2004) [Pubmed]
  9. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Jacinto, E., Guo, B., Arndt, K.T., Schmelzle, T., Hall, M.N. Mol. Cell (2001) [Pubmed]
  10. Saccharomyces cerevisiae Sit4 Phosphatase Is Active Irrespective of the Nitrogen Source Provided, and Gln3 Phosphorylation Levels Become Nitrogen Source-responsive in a sit4-deleted Strain. Tate, J.J., Feller, A., Dubois, E., Cooper, T.G. J. Biol. Chem. (2006) [Pubmed]
  11. The Tap42-protein phosphatase type 2A catalytic subunit complex is required for cell cycle-dependent distribution of actin in yeast. Wang, H., Jiang, Y. Mol. Cell. Biol. (2003) [Pubmed]
  12. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. Schmidt, A., Beck, T., Koller, A., Kunz, J., Hall, M.N. EMBO J. (1998) [Pubmed]
  13. Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast. Schmelzle, T., Beck, T., Martin, D.E., Hall, M.N. Mol. Cell. Biol. (2004) [Pubmed]
  14. Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots. Cooper, T.G. FEMS Microbiol. Rev. (2002) [Pubmed]
  15. Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2. Van Hoof, C., Martens, E., Longin, S., Jordens, J., Stevens, I., Janssens, V., Goris, J. Biochem. J. (2005) [Pubmed]
 
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