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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MMS1  -  Mms1p

Saccharomyces cerevisiae S288c

Synonyms: E3 ubiquitin-protein ligase linker protein MMS1, KIM3, Methyl methanesulfonate-sensitivity protein 1, RTT108, Regulator of Ty1 transposition protein 108, ...
 
 
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High impact information on MMS1

  • We screened for mutations that are lethal in combination with mcm10-1 and obtained seven mutants named slm1-slm6 for synthetically lethal with mcm10 [1].
  • Class 3 includes novel DNA repair genes represented by SLM2 and SLM6 [1].
  • MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae [2].
  • We have cloned and characterized one of the corresponding genes, MMS1, and show that the mms1 Delta mutant is dramatically sensitive to killing by MMS and mildly sensitive to UV radiation. mms1 Delta mutants display an elevated level of spontaneous DNA damage and genomic instability [2].

References

  1. Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability. Araki, Y., Kawasaki, Y., Sasanuma, H., Tye, B.K., Sugino, A. Genes Cells (2003) [Pubmed]
  2. MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae. Hryciw, T., Tang, M., Fontanie, T., Xiao, W. Mol. Genet. Genomics (2002) [Pubmed]
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