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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genomic Instability

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Disease relevance of Genomic Instability


High impact information on Genomic Instability


Chemical compound and disease context of Genomic Instability


Biological context of Genomic Instability


Anatomical context of Genomic Instability


Associations of Genomic Instability with chemical compounds


Gene context of Genomic Instability


Analytical, diagnostic and therapeutic context of Genomic Instability


  1. The Fanconi anaemia proteins, FAA and FAC, interact to form a nuclear complex. Kupfer, G.M., Näf, D., Suliman, A., Pulsipher, M., D'Andrea, A.D. Nat. Genet. (1997) [Pubmed]
  2. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Bassing, C.H., Suh, H., Ferguson, D.O., Chua, K.F., Manis, J., Eckersdorff, M., Gleason, M., Bronson, R., Lee, C., Alt, F.W. Cell (2003) [Pubmed]
  3. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Hartley, K.O., Gell, D., Smith, G.C., Zhang, H., Divecha, N., Connelly, M.A., Admon, A., Lees-Miller, S.P., Anderson, C.W., Jackson, S.P. Cell (1995) [Pubmed]
  4. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Wong, K.K., Maser, R.S., Bachoo, R.M., Menon, J., Carrasco, D.R., Gu, Y., Alt, F.W., DePinho, R.A. Nature (2003) [Pubmed]
  5. p53 tumor suppressor gene status and the degree of genomic instability in sporadic colorectal cancers. Kahlenberg, M.S., Stoler, D.L., Basik, M., Petrelli, N.J., Rodriguez-Bigas, M., Anderson, G.R. J. Natl. Cancer Inst. (1996) [Pubmed]
  6. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Mostoslavsky, R., Chua, K.F., Lombard, D.B., Pang, W.W., Fischer, M.R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M.M., Mills, K.D., Patel, P., Hsu, J.T., Hong, A.L., Ford, E., Cheng, H.L., Kennedy, C., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hottiger, M.O., Hursting, S., Barrett, J.C., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G.D., Alt, F.W. Cell (2006) [Pubmed]
  7. DNA repair, genome stability, and aging. Lombard, D.B., Chua, K.F., Mostoslavsky, R., Franco, S., Gostissa, M., Alt, F.W. Cell (2005) [Pubmed]
  8. Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Li, X., Manley, J.L. Cell (2005) [Pubmed]
  9. Genetic modulation of senescent phenotypes in Homo sapiens. Martin, G.M. Cell (2005) [Pubmed]
  10. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Muñoz, P., Blanco, R., Flores, J.M., Blasco, M.A. Nat. Genet. (2005) [Pubmed]
  11. Enhancement of genomic instability by 17beta-estradiol in minisatellite sequences of X-ray-transformed mouse 10T1/2 cells. Paquette, B. Carcinogenesis (1996) [Pubmed]
  12. Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. Kimura, M., Umegaki, K., Higuchi, M., Thomas, P., Fenech, M. J. Nutr. (2004) [Pubmed]
  13. Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice. Mirsalis, J.C., Shimon, J.A., Johnson, A., Fairchild, D., Kanazawa, N., Nguyen, T., de Boer, J., Glickman, B., Winegar, R.A. Environ. Mol. Mutagen. (2005) [Pubmed]
  14. Genomic instability in hepatocellular carcinoma revealed by using the random amplified polymorphic DNA method. Zhang, S.H., Cong, W.M., Xian, Z.H., Dong, H., Wu, M.C. J. Cancer Res. Clin. Oncol. (2004) [Pubmed]
  15. Folate deficiency, mismatch repair-dependent apoptosis, and human disease. Li, G.M., Presnell, S.R., Gu, L. J. Nutr. Biochem. (2003) [Pubmed]
  16. Defects in mismatch repair promote telomerase-independent proliferation. Rizki, A., Lundblad, V. Nature (2001) [Pubmed]
  17. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Brown, J.P., Wei, W., Sedivy, J.M. Science (1997) [Pubmed]
  18. PARP is important for genomic stability but dispensable in apoptosis. Wang, Z.Q., Stingl, L., Morrison, C., Jantsch, M., Los, M., Schulze-Osthoff, K., Wagner, E.F. Genes Dev. (1997) [Pubmed]
  19. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Donehower, L.A., Godley, L.A., Aldaz, C.M., Pyle, R., Shi, Y.P., Pinkel, D., Gray, J., Bradley, A., Medina, D., Varmus, H.E. Genes Dev. (1995) [Pubmed]
  20. The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1). Lengronne, A., Schwob, E. Mol. Cell (2002) [Pubmed]
  21. Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion. Du, J., Hannon, G.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  22. Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Reina-San-Martin, B., Nussenzweig, M.C., Nussenzweig, A., Difilippantonio, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  23. The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes. Ouellette, M.M., McDaniel, L.D., Wright, W.E., Shay, J.W., Schultz, R.A. Hum. Mol. Genet. (2000) [Pubmed]
  24. Overexpression of c-Myc alters G(1)/S arrest following ionizing radiation. Sheen, J.H., Dickson, R.B. Mol. Cell. Biol. (2002) [Pubmed]
  25. DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated. De, P., Peak, M.M., Rodgers, K.K. Mol. Cell. Biol. (2004) [Pubmed]
  26. Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. Franchitto, A., Pichierri, P. J. Cell Biol. (2002) [Pubmed]
  27. Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Rao, C.V., Yang, Y.M., Swamy, M.V., Liu, T., Fang, Y., Mahmood, R., Jhanwar-Uniyal, M., Dai, W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  28. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. de Murcia, J.M., Niedergang, C., Trucco, C., Ricoul, M., Dutrillaux, B., Mark, M., Oliver, F.J., Masson, M., Dierich, A., LeMeur, M., Walztinger, C., Chambon, P., de Murcia, G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  29. Overexpression and amplification of c-myc in the Syrian hamster kidney during estrogen carcinogenesis: a probable critical role in neoplastic transformation. Li, J.J., Hou, X., Banerjee, S.K., Liao, D.Z., Maggouta, F., Norris, J.S., Li, S.A. Cancer Res. (1999) [Pubmed]
  30. In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. James, S.J., Basnakian, A.G., Miller, B.J. Cancer Res. (1994) [Pubmed]
  31. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Risinger, J.I., Umar, A., Boyd, J., Berchuck, A., Kunkel, T.A., Barrett, J.C. Nat. Genet. (1996) [Pubmed]
  32. Genomic instability in Gadd45a-deficient mice. Hollander, M.C., Sheikh, M.S., Bulavin, D.V., Lundgren, K., Augeri-Henmueller, L., Shehee, R., Molinaro, T.A., Kim, K.E., Tolosa, E., Ashwell, J.D., Rosenberg, M.P., Zhan, Q., Fernández-Salguero, P.M., Morgan, W.F., Deng, C.X., Fornace, A.J. Nat. Genet. (1999) [Pubmed]
  33. Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases. Gangloff, S., Soustelle, C., Fabre, F. Nat. Genet. (2000) [Pubmed]
  34. Werner syndrome protein limits MYC-induced cellular senescence. Grandori, C., Wu, K.J., Fernandez, P., Ngouenet, C., Grim, J., Clurman, B.E., Moser, M.J., Oshima, J., Russell, D.W., Swisshelm, K., Frank, S., Amati, B., Dalla-Favera, R., Monnat, R.J. Genes Dev. (2003) [Pubmed]
  35. Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Cobb, J.A., Schleker, T., Rojas, V., Bjergbaek, L., Tercero, J.A., Gasser, S.M. Genes Dev. (2005) [Pubmed]
  36. Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Hunt, C.R., Dix, D.J., Sharma, G.G., Pandita, R.K., Gupta, A., Funk, M., Pandita, T.K. Mol. Cell. Biol. (2004) [Pubmed]
  37. DNA alterations in human aberrant crypt foci and colon cancers by random primed polymerase chain reaction. Luo, L., Li, B., Pretlow, T.P. Cancer Res. (2003) [Pubmed]
  38. Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase. Salloukh, H.F., Laneuville, P. Leukemia (2000) [Pubmed]
  39. Extended lifespan of Barrett's esophagus epithelium transduced with the human telomerase catalytic subunit: a useful in vitro model. Palanca-Wessels, M.C., Klingelhutz, A., Reid, B.J., Norwood, T.H., Opheim, K.E., Paulson, T.G., Feng, Z., Rabinovitch, P.S. Carcinogenesis (2003) [Pubmed]
  40. Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis. Maluf, S.W., Erdtmann, B. Cancer Genet. Cytogenet. (2001) [Pubmed]
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