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Gene Review:

MLC2 - Mlc2p

Saccharomyces cerevisiae S288c

Synonyms: Calmodulin-like myosin light chain MLC2, MYO1 light chain 2, Myosin light chain 2, Myosin-1 light chain, P9677.10, ...

Post, G.R. et al., Chan, W. et al., Luo, J. et al.

Post, Swiderski, Waldrop, Salty, Glembotski, Wolthuis, Mochizuki,

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Disease relevance of MLC2

Expression of constitutively active Ras (V12Ras) in cultured neonatal rat ventricular myocytes or targeted cardiac expression of V12Ras in transgenic mice induces myocardial cell growth and expression of genes that are markers of cardiac hypertrophy including atrial natriuretic factor (ANF) and myosin light chain-2 [1].

High impact information on MLC2

We also identify Mlc2p as the regulatory light chain for Myo1p and demonstrate its role in Myo1p ring disassembly, a function likely conserved among eukaryotes [2].
BSEP and MLC2 were overrepresented in a rat liver subcellular fraction enriched in canalicular membrane vesicles, and MLC2 colocalized with BSEP in the apical domain of hepatocytes and polarized WifB, HepG2, and Madin-Darby canine kidney cells [3].

References

Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes. Post, G.R., Swiderski, C., Waldrop, B.A., Salty, L., Glembotski, C.C., Wolthuis, R.M., Mochizuki, N. J. Biol. Chem. (2002) [Pubmed]
Identification and functional analysis of the essential and regulatory light chains of the only type II myosin Myo1p in Saccharomyces cerevisiae. Luo, J., Vallen, E.A., Dravis, C., Tcheperegine, S.E., Drees, B., Bi, E. J. Cell Biol. (2004) [Pubmed]
Myosin II regulatory light chain is required for trafficking of bile salt export protein to the apical membrane in Madin-Darby canine kidney cells. Chan, W., Calderon, G., Swift, A.L., Moseley, J., Li, S., Hosoya, H., Arias, I.M., Ortiz, D.F. J. Biol. Chem. (2005) [Pubmed]

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