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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

YEF1  -  Yef1p

Saccharomyces cerevisiae S288c

Synonyms: ATP-NADH kinase YEF1, SYGP-ORF17, YEL041W
 
 
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High impact information on YEF1

  • Purified Yef1 has similar nucleoside triphosphate specificity but substantially lower specific activity and less discrimination in favor of NAD versus NADH phosphorylation than Utr1 [1].
  • Three NAD kinase homologs, encoded by UTR1, POS5 and YEF1 genes, are found in the yeast Saccharomyces cerevisiae and proven to be important sources of NADPH for the cell [2].
 

Biological context of YEF1

  • The contributions of the other two enzymes were also demonstrated; however, these were observed only in the absence of the critical contributor, which was supported by complementation for some pos5 phenotypes by the overexpression of UTR1 and YEF1 [3].

References

  1. Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions. Bieganowski, P., Seidle, H.F., Wojcik, M., Brenner, C. J. Biol. Chem. (2006) [Pubmed]
  2. partial Rescue of pos5 Mutants by YEF1 and UTR1 Genes in Saccharomyces cerevisiae. Li, Y.F., Shi, F. Acta Biochim. Biophys. Sin. (Shanghai) (2006) [Pubmed]
  3. Identification of ATP-NADH kinase isozymes and their contribution to supply of NADP(H) in Saccharomyces cerevisiae. Shi, F., Kawai, S., Mori, S., Kono, E., Murata, K. FEBS J. (2005) [Pubmed]
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