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Gene Review:

BOI2 - Boi2p

Saccharomyces cerevisiae S288c

Synonyms: BEB1, Protein BEB1, Protein BOI2, YER114C

Matsui, Y. et al., Hertveldt, K. et al., Toya, M. et al., Hallett, M.A. et al.

Hallett, Lo, Bender, Hertveldt, Robben, Volckaert, Matsui, Matsui, Akada, Toh-e,

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Disease relevance of BOI2

Interaction selection by biopanning from a fragmented yeast proteome displayed on filamentous phage particles was successful in identifying proline-rich fragments of Boi1p and Boi2p [1].

High impact information on BOI2

A BOI2 homologue, BOI1, was identified as a gene whose overexpression inhibited cell growth [2].
Analysis using several truncated versions of BOI2 revealed that the COOH-terminal half, which contains the pleckstrin homology domain is essential for the function of Boi2p in cell growth, while the NH2-terminal half is not, and the NH2-terminal half might be required for modulating the function of Bem1p [2].

Biological context of BOI2

Boi2p has a proline-rich sequence that is critical for displaying the Boi2p-Bem1p two-hybrid interaction, an SH3 domain in its NH2-terminal half, and a pleckstrin homology domain in its COOH-terminal half [2].
Boi1 and Boi2 are localized to the periphery of buds during much of the budding cycle and to necks late in the cell cycle [3].

Other interactions of BOI2

Pob1p is homologous to two functionally redundant Saccharomyces cerevisiae proteins, Boi1p and Boi2p, which are necessary for cell growth and relevant to bud formation [4].

References

Whole Genome Phage Display Selects for Proline-rich Boi Polypeptides against Bem1p. Hertveldt, K., Robben, J., Volckaert, G. Biotechnol. Lett. (2006) [Pubmed]
Yeast src homology region 3 domain-binding proteins involved in bud formation. Matsui, Y., Matsui, R., Akada, R., Toh-e, A. J. Cell Biol. (1996) [Pubmed]
Probing the importance and potential roles of the binding of the PH-domain protein Boi1 to acidic phospholipids. Hallett, M.A., Lo, H.S., Bender, A. BMC Cell Biol. (2002) [Pubmed]
Fission yeast Pob1p, which is homologous to budding yeast Boi proteins and exhibits subcellular localization close to actin patches, is essential for cell elongation and separation. Toya, M., Iino, Y., Yamamoto, M. Mol. Biol. Cell (1999) [Pubmed]

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