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Gene Review

GLO3  -  Glo3p

Saccharomyces cerevisiae S288c

Synonyms: ADP-ribosylation factor GTPase-activating protein GLO3, ARF GAP GLO3, YER122C
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High impact information on GLO3

  • Further, we demonstrate novel direct interactions of coatomer subunits with regulatory proteins: beta'- and gamma-COP interact with the ARF-GTP-activating protein (GAP) Glo3p, but not Gcs1p, and beta- and epsilon-COP interact with ARF-GTP [1].
  • Gcs1p and the products of two newly identified genes, SPS18 and GLO3, constitute a family of novel Zn-finger proteins [2].
  • Gene deletion experiments of other family members showed that only GLO3 deletion resulted in impaired retrieval of dilysine-tagged proteins back to the ER [3].
  • The corresponding RET4 gene was found to encode Glo3p, a GTPase-activating protein (GAP) specific for ADP-ribosylation factor (ARF) [3].
  • The Glo3 protein belongs to a family of zinc finger proteins that may include additional ARF-GAPs [3].

Anatomical context of GLO3


Other interactions of GLO3

  • These findings suggest that Glo3 and Gcs1 ARF GAPs mediate retrograde vesicular transport from the Golgi to the ER [4].


  1. COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. Eugster, A., Frigerio, G., Dale, M., Duden, R. EMBO J. (2000) [Pubmed]
  2. A member of a novel family of yeast 'zn-finger' proteins mediates the transition from stationary phase to cell proliferation. Ireland, L.S., Johnston, G.C., Drebot, M.A., Dhillon, N., DeMaggio, A.J., Hoekstra, M.F., Singer, R.A. EMBO J. (1994) [Pubmed]
  3. The ADP-ribosylation factor GTPase-activating protein Glo3p is involved in ER retrieval. Dogic, D., de Chassey, B., Pick, E., Cassel, D., Lefkir, Y., Hennecke, S., Cosson, P., Letourneur, F. Eur. J. Cell Biol. (1999) [Pubmed]
  4. Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function. Poon, P.P., Cassel, D., Spang, A., Rotman, M., Pick, E., Singer, R.A., Johnston, G.C. EMBO J. (1999) [Pubmed]
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