Gene Review:
GCS1 - Gcs1p
Saccharomyces cerevisiae S288c
Synonyms:
ADP-ribosylation factor GTPase-activating protein GCS1, ARF GAP GCS1, YDL226C
- The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network. Poon, P.P., Nothwehr, S.F., Singer, R.A., Johnston, G.C. J. Cell Biol. (2001)
- COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. Eugster, A., Frigerio, G., Dale, M., Duden, R. EMBO J. (2000)
- A member of a novel family of yeast 'zn-finger' proteins mediates the transition from stationary phase to cell proliferation. Ireland, L.S., Johnston, G.C., Drebot, M.A., Dhillon, N., DeMaggio, A.J., Hoekstra, M.F., Singer, R.A. EMBO J. (1994)
- Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi. Wong, T.A., Fairn, G.D., Poon, P.P., Shmulevitz, M., McMaster, C.R., Singer, R.A., Johnston, G.C. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Prenylated isoforms of yeast casein kinase I, including the novel Yck3p, suppress the gcs1 blockage of cell proliferation from stationary phase. Wang, X., Hoekstra, M.F., DeMaggio, A.J., Dhillon, N., Vancura, A., Kuret, J., Johnston, G.C., Singer, R.A. Mol. Cell. Biol. (1996)
- GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro. Blader, I.J., Cope, M.J., Jackson, T.R., Profit, A.A., Greenwood, A.F., Drubin, D.G., Prestwich, G.D., Theibert, A.B. Mol. Biol. Cell (1999)
- The functional relationship between the Cdc50p-Drs2p putative aminophospholipid translocase and the Arf GAP Gcs1p in vesicle formation in the retrieval pathway from yeast early endosomes to the TGN. Sakane, H., Yamamoto, T., Tanaka, K. Cell Struct. Funct. (2006)
- Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein. Poon, P.P., Wang, X., Rotman, M., Huber, I., Cukierman, E., Cassel, D., Singer, R.A., Johnston, G.C. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function. Poon, P.P., Cassel, D., Spang, A., Rotman, M., Pick, E., Singer, R.A., Johnston, G.C. EMBO J. (1999)
- Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments. Liu, Y.W., Huang, C.F., Huang, K.B., Lee, F.J. Mol. Biol. Cell (2005)
- The Arf-GTPase-activating protein Gcs1p is essential for sporulation and regulates the phospholipase D Spo14p. Connolly, J.E., Engebrecht, J. Eukaryotic Cell (2006)
- Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. Venkateswarlu, K., Oatey, P.B., Tavaré, J.M., Jackson, T.R., Cullen, P.J. Biochem. J. (1999)