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Gene Review: 

FAU1  -  5-formyltetrahydrofolate cyclo-ligase

Saccharomyces cerevisiae S288c

Synonyms: 5,10-methenyl-tetrahydrofolate synthetase, MTHFS, Methenyl-THF synthetase, YER183C
 
 
 
 
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Disease relevance of FAU1

  • The yeast enzyme was expressed in Escherichia coli, and the purified recombinant enzyme exhibited kinetics similar to previously purified MTHFS [1].
 

High impact information on FAU1

  • In yeast lacking MTHFS along with both AICAR transformylases, 5-CHO-THF was elevated 12-fold over wild type [1].
  • A BLAST search of the yeast genome using the human MTHFS sequence revealed a 211-amino acid open reading frame (YER183c) with significant homology [1].
  • However, when the MTHFS gene was disrupted in a strain lacking the de novo folate biosynthesis pathway, folinic acid (5-CHO-THF) could no longer support the folate requirement [1].
 

Associations of FAU1 with chemical compounds

  • Only one enzyme is known that utilizes 5-CHO-THF as a substrate: 5,10-methenyltetrahydrofolate synthetase (MTHFS) [1].

References

  1. Cloning and characterization of methenyltetrahydrofolate synthetase from Saccharomyces cerevisiae. Holmes, W.B., Appling, D.R. J. Biol. Chem. (2002) [Pubmed]
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