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Chemical Compound Review

leucovorin     (2R)-2-[[4-[(2-amino-5- methanoyl-4-oxo-1,6...

Synonyms: Leucal, Welcovorin, citrovorum, Novo-folacid, l-Leucovorin, ...
 
 
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Disease relevance of folinic acid

 

Psychiatry related information on folinic acid

 

High impact information on folinic acid

 

Chemical compound and disease context of folinic acid

 

Biological context of folinic acid

 

Anatomical context of folinic acid

 

Associations of folinic acid with other chemical compounds

 

Gene context of folinic acid

  • METHODS: Genotype analysis of the MTHFR gene was done in 236 patients who started MTX treatment with (n = 157) or without (n = 79) folic or folinic acid supplementation [35].
  • FOL1 is an essential gene and the nongrowth phenotype of the fol1 deletion leads to a recessive auxotrophy for folinic acid (5'-formyltetrahydrofolate) [25].
  • Since deletion of yeast FOL2 leads to a recessive auxotrophy for folinic acid, we used a yeast fol2Delta mutant for an in vivo functional assay of heterologous GTP cyclohydrolases I [36].
  • Folinic acid enhances TS inhibition by increasing the intracellular pool of folates that stabilize the 5FU-TS complex [37].
  • Mutant cells bearing a fol3 mutation require folinic acid for growth and have no dihydrofolate synthetase activity [38].
 

Analytical, diagnostic and therapeutic context of folinic acid

References

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  19. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Daniele, B., Perrone, F., Gallo, C., Pignata, S., De Martino, S., De Vivo, R., Barletta, E., Tambaro, R., Abbiati, R., D'Agostino, L. Gut (2001) [Pubmed]
  20. Spontaneous or imposed circadian changes in plasma concentrations of 5-fluorouracil coadministered with folinic acid and oxaliplatin: relationship with mucosal toxicity in patients with cancer. Metzger, G., Massari, C., Etienne, M.C., Comisso, M., Brienza, S., Touitou, Y., Milano, G., Bastian, G., Misset, J.L., Lévi, F. Clin. Pharmacol. Ther. (1994) [Pubmed]
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  23. Phase I clinical and pharmacokinetic study of leucovorin and infusional hepatic arterial fluorouracil. Kerr, D.J., Ledermann, J.A., McArdle, C.S., Buckels, J., Neoptolemos, J., Seymour, M., Doughty, J., Budden, J., Taylor, I. J. Clin. Oncol. (1995) [Pubmed]
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  25. Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth. Güldener, U., Koehler, G.J., Haussmann, C., Bacher, A., Kricke, J., Becher, D., Hegemann, J.H. Mol. Biol. Cell (2004) [Pubmed]
  26. Protection with single-dose folinic acid against bone-marrow depression by long-acting diaminopyrimidines. Douglas, I.D., Gordon, M.Y., Prentice, G.H., Hill, B.T., Price, L.A. Lancet (1977) [Pubmed]
  27. Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid. Moran, R.G., Scanlon, K.L. Cancer Res. (1991) [Pubmed]
  28. Phase I trial of intraperitoneal iododeoxyuridine with and without intravenous high-dose folinic acid in the treatment of advanced malignancies primarily confined to the peritoneal cavity: flow cytometric and pharmacokinetic analysis. Morgan, R.J., Newman, E.M., Doroshow, J.H., McGonigle, K., Margolin, K., Raschko, J., Chow, W., Somlo, G., Leong, L., Tetef, M., Shibata, S., Hamasaki, V., Carroll, M., Vasilev, S., Akman, S., Coluzzi, P., Wagman, L., Longmate, J., Paz, B., Yen, Y., Klevecz, R. Cancer Res. (1998) [Pubmed]
  29. 5-Methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid (folinic acid), and folic acid requirements of normal and Rous sarcoma virus-infected chicken fibroblasts. Balk, S.D., LeStourgeon, D., Mitchell, R.S. Cancer Res. (1978) [Pubmed]
  30. Progressive intracranial calcification in dihydropteridine reductase deficiency prior to folinic acid therapy. Woody, R.C., Brewster, M.A., Glasier, C. Neurology (1989) [Pubmed]
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  33. Phase I trial of dipyridamole with 5-fluorouracil and folinic acid. Budd, G.T., Jayaraj, A., Grabowski, D., Adelstein, D., Bauer, L., Boyett, J., Bukowski, R., Murthy, S., Weick, J. Cancer Res. (1990) [Pubmed]
  34. Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells. Dixon, K.H., Mulligan, T., Chung, K.N., Elwood, P.C., Cowan, K.H. J. Biol. Chem. (1992) [Pubmed]
  35. The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients. van Ede, A.E., Laan, R.F., Blom, H.J., Huizinga, T.W., Haagsma, C.J., Giesendorf, B.A., de Boo, T.M., van de Putte, L.B. Arthritis Rheum. (2001) [Pubmed]
  36. Complementation of the fol2 deletion in Saccharomyces cerevisiae by human and Escherichia coli genes encoding GTP cyclohydrolase I. Mancini, R., Saracino, F., Buscemi, G., Fischer, M., Schramek, N., Bracher, A., Bacher, A., Gütlich, M., Carbone, M.L. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  37. 5-fluorouracil: a pharmacological paradigm in the use of cytotoxics. Thomas, D.M., Zalcberg, J.R. Clin. Exp. Pharmacol. Physiol. (1998) [Pubmed]
  38. Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae. Cherest, H., Thomas, D., Surdin-Kerjan, Y. J. Biol. Chem. (2000) [Pubmed]
  39. 18F-FDG PET is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer. Cascini, G.L., Avallone, A., Delrio, P., Guida, C., Tatangelo, F., Marone, P., Aloj, L., De Martinis, F., Comella, P., Parisi, V., Lastoria, S. J. Nucl. Med. (2006) [Pubmed]
  40. Effective correction of hyperhomocysteinemia in hemodialysis patients by intravenous folinic acid and pyridoxine therapy. Touam, M., Zingraff, J., Jungers, P., Chadefaux-Vekemans, B., Drüeke, T., Massy, Z.A. Kidney Int. (1999) [Pubmed]
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