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Gene Review:

KRT37 - keratin 37, type I

Homo sapiens

Synonyms: HA7, HHA7, HKA7, Hair keratin, type I Ha7, K37, ...

Jave-Suarez, L.F. et al., Schoeffter, P. et al.

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High impact information on KRT37

This suggested an androgen-controlled expression of the hHa7 gene [1].
Our study detected hHa7 as the first gene in hair follicle trichocytes whose expression appears to be directly regulated by androgens [1].
Moreover, homology search for the semipalindromic androgen receptor-binding element (ARE) consensus sequence GG(A)/(T)ACAnnnTGTTCT in the proximal hHa7 promoter revealed three putative ARE motifs [1].
Their function as AR-responsive elements, either individually or in concert within the hHa7 promoter, could be further confirmed by transfection studies with or without an AR expression vector in PtK2 and prostate PC3-Arwt cells, respectively in the presence or absence of a synthetic androgen [1].
Especially in HA7 cells which express lower receptor levels, a number of drugs failed to display agonism (e.g. buspirone or MDL 73005), whereas in HA6 cells they acted as partial agonists [2].

Analytical, diagnostic and therapeutic context of KRT37

Electrophoretic mobility shift assays demonstrated the specific binding of AR to all three hHa7 AREs [1].

References

Androgen regulation of the human hair follicle: the type I hair keratin hHa7 is a direct target gene in trichocytes. Jave-Suarez, L.F., Langbein, L., Winter, H., Praetzel, S., Rogers, M.A., Schweizer, J. J. Invest. Dermatol. (2004) [Pubmed]
Inhibition of cAMP accumulation via recombinant human serotonin 5-HT1A receptors: considerations on receptor effector coupling across systems. Schoeffter, P., Bobirnac, I., Boddeke, E., Hoyer, D. Neuropharmacology (1997) [Pubmed]

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