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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KRT36  -  keratin 36, type I

Homo sapiens

Synonyms: HA6, HHA6, HKA6, Hair keratin, type I Ha6, K36, ...
 
 
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High impact information on KRT36

  • Inhibition of forskolin-stimulated cyclic AMP accumulation was measured in two stable HeLa cell lines HA6 and HA7 expressing different levels of recombinant human 5-HT1A receptors [1].
  • Especially in HA7 cells which express lower receptor levels, a number of drugs failed to display agonism (e.g. buspirone or MDL 73005), whereas in HA6 cells they acted as partial agonists [1].
  • The three above mentioned ligands were tested on HeLa cells (cell line HA6) expressing recombinant human 5-HT1A receptors for their effects on forskolin-stimulated cAMP accumulation in intact cells [2].
  • Inconsistencies, however, were found for the antagonists NAN-190 and pindolol; only one inhibition constant was determined for HA6 cells, but two affinities were detected with cortical tissue [3].
  • 1. The binding characteristics of tritium labeled 8-hydroxy-dipropyl-aminotetralin, or [3H]8-OH-DPAT, to the serotonin1A (5-HT1A) receptor in the stably transfected HeLa cell clone HA6 and in human cortical tissue were examined and compared [3].
 

Anatomical context of KRT36

  • 3. In saturation experiments, at least two affinity states were unequivocally detected in the HA6 cell line and the human cortical tissue [3].

References

  1. Inhibition of cAMP accumulation via recombinant human serotonin 5-HT1A receptors: considerations on receptor effector coupling across systems. Schoeffter, P., Bobirnac, I., Boddeke, E., Hoyer, D. Neuropharmacology (1997) [Pubmed]
  2. Structure activity relationship of homochiral 7-substituted 1-aminoindans as 5-HT1A receptor ligands. Landsiedel-Maier, D., Frahm, A.W. Arch. Pharm. (Weinheim) (1998) [Pubmed]
  3. The human 5-HT1A receptor: comparison of its binding properties in transfected cells and cortical tissue. Pou, C., Nénonéné, E.K., Reader, T.A., Fargin, A. Gen. Pharmacol. (1997) [Pubmed]
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