The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DNAH11  -  dynein, axonemal, heavy chain 11

Homo sapiens

Synonyms: Axonemal beta dynein heavy chain 11, CILD7, Ciliary dynein heavy chain 11, DNAHBL, DNAHC11, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DNAH11


High impact information on DNAH11

  • We conclude that mutations in the coding region of DNAH11 account for situs inversus totalis and probably a minority of cases of PCD [1].
  • Sequence analysis of V(H) and V(L) regions of RH-14 showed that V(H) is derived from germ-line gene V3-7, a member of the V(H)3 family, and V(L) is derived from DPL 11, a member of the V(lambda)2 family [2].
  • The IgVL/lambda genes belonged to the Vlambda1 family (DPL2, DPL5, DPL8nf), the Vlambda2 family (DPL11, n = 2) and to the Vlambda6 family (IGLV6S1); 6/6 IgVL genes showed somatic mutations, the R/S ratio (CDR) was > 3 in 3/6 IgVL genes and the mean R/S ratio of all IgVL was 3.0 (CDR) and 2.3 (FR), suggesting an antigen-dependent selection [3].
  • These combinations utilized two genes from the Vlambda II and IIIb families (closest germline genes DPL11 and hsigg11150) and three genes from the VH1, VH3 and VH4 families (VH26, 4.34 and hv1L1) [4].

Biological context of DNAH11


Analytical, diagnostic and therapeutic context of DNAH11

  • Sequence analysis of the DNAH11 gene in an additional 6 selected PCD sibships that shared DNAH11 alleles revealed polymorphic variants and an R3004Q substitution in a conserved position that might be pathogenic [1].


  1. Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia. Bartoloni, L., Blouin, J.L., Pan, Y., Gehrig, C., Maiti, A.K., Scamuffa, N., Rossier, C., Jorissen, M., Armengot, M., Meeks, M., Mitchison, H.M., Chung, E.M., Delozier-Blanchet, C.D., Craigen, W.J., Antonarakis, S.E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis. Ravirajan, C.T., Rahman, M.A., Papadaki, L., Griffiths, M.H., Kalsi, J., Martin, A.C., Ehrenstein, M.R., Latchman, D.S., Isenberg, D.A. Eur. J. Immunol. (1998) [Pubmed]
  3. Molecular analysis of rheumatoid factor (RF)-negative B cell hybridomas from rheumatoid synovial tissue: evidence for an antigen-induced stimulation with selection of high mutated IgVH and low mutated IgVL/lambda genes. Krenn, V., König, A., Hensel, F., Berek, C., Souto Carneiro, M.M., Haedicke, W., Wang, Y., Vollmers, H., Müller-Hermelink, H.K. Clin. Exp. Immunol. (1999) [Pubmed]
  4. Molecular cloning and characterization of human thyroid peroxidase autoantibodies of lambda light chain type. Portolano, S., Prummel, M.F., Rapoport, B., McLachlan, S.M. Mol. Immunol. (1995) [Pubmed]
WikiGenes - Universities