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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CBR3  -  carbonyl reductase 3

Homo sapiens

Synonyms: HEL-S-25, NADPH-dependent carbonyl reductase 3, SDR21C2, hCBR3
 
 
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High impact information on CBR3

  • The structure reveals that the two calcium-binding regions on C2cPLA2 that display hydrophobic residues, CBR1 and CBR3, are partially inserted into the core of the membrane [1].
  • In addition, DNA variation panels from 10 ethnic groups presented a wide range of CBR3 V244M genotype distributions [2].
  • We pinpointed a single nucleotide polymorphism in CBR3 (CBR3 V244M) that encodes for a V244 to M244 change [2].
  • Assays with NADP(H) demonstrated a higher V(maxNADP(H)) (1.6-fold) and increased catalytic efficiency (V(maxNADP(H))/K(mNADP(H))) for CBR3 M244 compared with CBR3 V244 (p = 0.013) [2].
 

Biological context of CBR3

References

  1. Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance. Ball, A., Nielsen, R., Gelb, M.H., Robinson, B.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3). Lakhman, S.S., Ghosh, D., Blanco, J.G. Drug Metab. Dispos. (2005) [Pubmed]
  3. Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. Watanabe, K., Sugawara, C., Ono, A., Fukuzumi, Y., Itakura, S., Yamazaki, M., Tashiro, H., Osoegawa, K., Soeda, E., Nomura, T. Genomics (1998) [Pubmed]
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