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Gene Review

CBR1  -  carbonyl reductase 1

Homo sapiens

Synonyms: CBR, CRN, NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, Prostaglandin-E(2) 9-reductase, ...
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Disease relevance of CBR1


Psychiatry related information on CBR1

  • CONCLUSIONS: the WHO CBR programme is highly effective for disabled people in the community being trained at home, for both children and adults, and yields similar results in different types of society; it can be accomplished at very low cost by recruiting volunteers, and mobilizes human resources in the community while promoting self-esteem [6].

High impact information on CBR1


Chemical compound and disease context of CBR1


Biological context of CBR1


Anatomical context of CBR1


Associations of CBR1 with chemical compounds


Physical interactions of CBR1


Enzymatic interactions of CBR1

  • 4. Recombinant human carbonyl reductase catalysed low-affinity reduction of E-10-oxonortriptyline with preferential transfer of the pro-4S-3H of labelled NADPH [26].

Other interactions of CBR1


Analytical, diagnostic and therapeutic context of CBR1


  1. Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein. Wermuth, B., Bohren, K.M., Heinemann, G., von Wartburg, J.P., Gabbay, K.H. J. Biol. Chem. (1988) [Pubmed]
  2. Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease. Balcz, B., Kirchner, L., Cairns, N., Fountoulakis, M., Lubec, G. J. Neural Transm. Suppl. (2001) [Pubmed]
  3. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV). Cheon, M.S., Shim, K.S., Kim, S.H., Hara, A., Lubec, G. Amino Acids (2003) [Pubmed]
  4. Induction of a human carbonyl reductase gene located on chromosome 21. Forrest, G.L., Akman, S., Krutzik, S., Paxton, R.J., Sparkes, R.S., Doroshow, J., Felsted, R.L., Glover, C.J., Mohandas, T., Bachur, N.R. Biochim. Biophys. Acta (1990) [Pubmed]
  5. Protection against daunorubicin cytotoxicity by expression of a cloned human carbonyl reductase cDNA in K562 leukemia cells. Gonzalez, B., Akman, S., Doroshow, J., Rivera, H., Kaplan, W.D., Forrest, G.L. Cancer Res. (1995) [Pubmed]
  6. Community-based rehabilitation--outcome for the disabled in the Philippines and Zimbabwe. Lagerkvist, B. Disability and rehabilitation. (1992) [Pubmed]
  7. Functional genomic analysis of apoptotic DNA degradation in C. elegans. Parrish, J.Z., Xue, D. Mol. Cell (2003) [Pubmed]
  8. Isoleucine-15 of rainbow trout carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase is critical for coenzyme (NADPH) binding. Guan, G., Todo, T., Tanaka, M., Young, G., Nagahama, Y. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance. Ball, A., Nielsen, R., Gelb, M.H., Robinson, B.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  10. Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase. Krook, M., Ghosh, D., Strömberg, R., Carlquist, M., Jörnvall, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  11. Arterial baroreflex control of sympathetic nerve activity during elevation of blood pressure in normal man: dominance of aortic baroreflexes. Sanders, J.S., Ferguson, D.W., Mark, A.L. Circulation (1988) [Pubmed]
  12. Mechanistic roles of Ser-114, Tyr-155, and Lys-159 in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. Hwang, C.C., Chang, Y.H., Hsu, C.N., Hsu, H.H., Li, C.W., Pon, H.I. J. Biol. Chem. (2005) [Pubmed]
  13. Regulation of the steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase gene in Comamonas testosteroni. Xiong, G., Maser, E. J. Biol. Chem. (2001) [Pubmed]
  14. Characterization of S-hexylglutathione-binding proteins of human hepatocellular carcinoma: separation of enoyl-CoA isomerase from an Alpha class glutathione transferase form. Kajihara-Kano, H., Hayakari, M., Satoh, K., Tomioka, Y., Mizugaki, M., Tsuchida, S. Biochem. J. (1997) [Pubmed]
  15. Effect of asthma and ventilatory loading on arterial PCO2 of humans during submaximal exercise. Forster, H.V., Dunning, M.B., Lowry, T.F., Erickson, B.K., Forster, M.A., Pan, L.G., Brice, A.G., Effros, R.M. J. Appl. Physiol. (1993) [Pubmed]
  16. Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3). Lakhman, S.S., Ghosh, D., Blanco, J.G. Drug Metab. Dispos. (2005) [Pubmed]
  17. Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. Watanabe, K., Sugawara, C., Ono, A., Fukuzumi, Y., Itakura, S., Yamazaki, M., Tashiro, H., Osoegawa, K., Soeda, E., Nomura, T. Genomics (1998) [Pubmed]
  18. Characterization of multiple Chinese hamster carbonyl reductases. Terada, T., Sugihara, Y., Nakamura, K., Sato, R., Sakuma, S., Fujimoto, Y., Fujita, T., Inazu, N., Maeda, M. Chem. Biol. Interact. (2001) [Pubmed]
  19. An unbiased cell morphology-based screen for new, biologically active small molecules. Tanaka, M., Bateman, R., Rauh, D., Vaisberg, E., Ramachandani, S., Zhang, C., Hansen, K.C., Burlingame, A.L., Trautman, J.K., Shokat, K.M., Adams, C.L. PLoS Biol. (2005) [Pubmed]
  20. Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver. Ohara, H., Miyabe, Y., Deyashiki, Y., Matsuura, K., Hara, A. Biochem. Pharmacol. (1995) [Pubmed]
  21. Carbonyl reductase from human testis: purification and comparison with carbonyl reductase from human brain and rat testis. Inazu, N., Ruepp, B., Wirth, H., Wermuth, B. Biochim. Biophys. Acta (1992) [Pubmed]
  22. Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase. Wermuth, B. J. Biol. Chem. (1981) [Pubmed]
  23. Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity. Forrest, G.L., Akman, S., Doroshow, J., Rivera, H., Kaplan, W.D. Mol. Pharmacol. (1991) [Pubmed]
  24. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. Bateman, R.L., Rauh, D., Tavshanjian, B., Shokat, K.M. J. Biol. Chem. (2008) [Pubmed]
  25. Inactivation of carbonyl reductase from human brain by phenylglyoxal and 2,3-butanedione: a comparison with aldehyde reductase and aldose reductase. Bohren, K.M., von Wartburg, J.P., Wermuth, B. Biochim. Biophys. Acta (1987) [Pubmed]
  26. Stereoselective reversible ketone formation from 10-hydroxylated nortriptyline metabolites in human liver. Breyer-Pfaff, U., Nill, K. Xenobiotica (1995) [Pubmed]
  27. Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells. Lemieux, N., Malfoy, B., Forrest, G.L. Genomics (1993) [Pubmed]
  28. Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol. Atalla, A., Breyer-Pfaff, U., Maser, E. Xenobiotica (2000) [Pubmed]
  29. Identification of the reactive cysteine residue (Cys227) in human carbonyl reductase. Tinguely, J.N., Wermuth, B. Eur. J. Biochem. (1999) [Pubmed]
  30. Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung. Finckh, C., Atalla, A., Nagel, G., Stinner, B., Maser, E. Chem. Biol. Interact. (2001) [Pubmed]
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