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Gene Review:

ipgD - secreted protein

Shigella flexneri 5a str. M90T

Allaoui, A. et al., Lan, R. et al., Lan, R. et al.

Lan, Alles, Donohoe, Martinez, Reeves,

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Disease relevance of ipgD

Characterization of the Shigella flexneri ipgD and ipgF genes, which are located in the proximal part of the mxi locus [1].

High impact information on ipgD

Two strains were found in the pINV B form by using the ipgD sequence, with one strain having an mxiA sequence similar to the divergent sequence of D1 [2].
Two forms of the virulence plasmid pINV have been identified in Shigella strains by using the sequences of ipgD and mxiA genes, and all but two of our EIEC strains have pINV A [2].
The D1 pINV plasmid is a recombinant with ipgD gene more closely related to those of pINV A but with mxiA and mxiC genes more closely related to those of pINV B [3].
We report here the characterization of the ipgD, ipgE, and ipgF genes, which are located in the 5' end of the mxi locus [1].

References

Characterization of the Shigella flexneri ipgD and ipgF genes, which are located in the proximal part of the mxi locus. Allaoui, A., Ménard, R., Sansonetti, P.J., Parsot, C. Infect. Immun. (1993) [Pubmed]
Molecular evolutionary relationships of enteroinvasive Escherichia coli and Shigella spp. Lan, R., Alles, M.C., Donohoe, K., Martinez, M.B., Reeves, P.R. Infect. Immun. (2004) [Pubmed]
Molecular evolution of large virulence plasmid in Shigella clones and enteroinvasive Escherichia coli. Lan, R., Lumb, B., Ryan, D., Reeves, P.R. Infect. Immun. (2001) [Pubmed]

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