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Gene Review:

ipaH2.5 - invasion plasmid antigen H

Shigella flexneri 5a str. M90T

Buysse, J.M. et al., Gaudio, P.A. et al., Sethabutr, O. et al., Vu, D.T. et al., Venkatesan, M.M. et al.

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Disease relevance of ipaH2.5

Detection of the ipaH gene by PCR is far more sensitive than detection by standard culture and is highly correlated with evidence of Shigella transmission among family contacts [1].
Detection of Shigellae and enteroinvasive Escherichia coli by amplification of the invasion plasmid antigen H DNA sequence in patients with dysentery [2].
Detection of Shigella by a PCR assay targeting the ipaH gene suggests increased prevalence of shigellosis in Nha Trang, Vietnam [3].

High impact information on ipaH2.5

The DNA sequences of ipaH2.5 and ipaH1.4 indicate that these genes are truncated versions of ipaH7 [4].
Oligonucleotide probes covering discrete 24 bp segments of the ipaH7.8 gene and sequences flanking the ipaH4.5 (probe H25) and ipaH2.5 (probe H24) loci were used to define the extent of homology among invasion plasmid copies of ipaH in S. flexneri serotypes 1, 2 and 5 and in S. sonnei [5].

References

Utility of a polymerase chain reaction diagnostic system in a study of the epidemiology of shigellosis among dysentery patients, family contacts, and well controls living in a shigellosis-endemic area. Gaudio, P.A., Sethabutr, O., Echeverria, P., Hoge, C.W. J. Infect. Dis. (1997) [Pubmed]
Detection of Shigellae and enteroinvasive Escherichia coli by amplification of the invasion plasmid antigen H DNA sequence in patients with dysentery. Sethabutr, O., Venkatesan, M., Murphy, G.S., Eampokalap, B., Hoge, C.W., Echeverria, P. J. Infect. Dis. (1993) [Pubmed]
Detection of Shigella by a PCR assay targeting the ipaH gene suggests increased prevalence of shigellosis in Nha Trang, Vietnam. Vu, D.T., Sethabutr, O., Von Seidlein, L., Tran, V.T., Do, G.C., Bui, T.C., Le, H.T., Lee, H., Houng, H.S., Hale, T.L., Clemens, J.D., Mason, C., Dang, D.T. J. Clin. Microbiol. (2004) [Pubmed]
Sequence variation in two ipaH genes of Shigella flexneri 5 and homology to the LRG-like family of proteins. Venkatesan, M.M., Buysse, J.M., Hartman, A.B. Mol. Microbiol. (1991) [Pubmed]
Genetic polymorphism of the ipaH multicopy antigen gene in Shigella spps. and enteroinvasive Escherichia coli. Buysse, J.M., Hartman, A.B., Strockbine, N., Venkatesan, M. Microb. Pathog. (1995) [Pubmed]

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