The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Dysentery, Bacillary

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dysentery, Bacillary


High impact information on Dysentery, Bacillary


Chemical compound and disease context of Dysentery, Bacillary


Biological context of Dysentery, Bacillary


Anatomical context of Dysentery, Bacillary

  • Here, we determine that the PhoP/PhoQ system also regulates virulence in the aetiological agent of bacillary dysentery, Shigella flexneri, even though this pathogen escapes from the phagosome into the cytoplasm of the host cell [19].
  • Furthermore, the mean number of activated B cells that secreted anti-S. sonnei LPS antibodies was significantly higher among patients with S. sonnei shigellosis than it was among patients with non-Shigella diarrhea (2.5/10(6) cells; standard error, 1.0) and healthy subjects (5.1/10(6) cells; standard error, 2.3) (P less than 0.05) [20].
  • Shigella flexneri, the aetiological agent of bacillary dysentery, induces apoptosis in macrophages which, in agony, specifically release mature interleukin-1 beta (IL-1 beta) [21].
  • Children with complicated shigellosis had more polarized neutrophils with FMLP at 10(-7) and 10(-6) M (P < 0.05) and with LPS than children with uncomplicated shigellosis (P < 0.05) [22].

Gene context of Dysentery, Bacillary

  • Because IGFBPs modulate the concentrations and availability of IGFs in serum, IGF-binding proteins (IGFBPs) were measured along with IGF-I and IGF-II before and after 21 days of refeeding in 22 undernourished Bangladeshi children (2-4 yr of age) with shigellosis [23].
  • Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2 [24].
  • Shigellosis was not associated with increased humoral IL-1 beta, endotoxin, or antigen-antibody complexes [25].
  • Blockade of CD14 aggravates experimental shigellosis [26].
  • It is possible that intracerebral production of TNF alpha and IL-1 beta plays a role in neurological disturbances of human shigellosis [27].

Analytical, diagnostic and therapeutic context of Dysentery, Bacillary


  1. Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Sansonetti, P.J., Phalipon, A., Arondel, J., Thirumalai, K., Banerjee, S., Akira, S., Takeda, K., Zychlinsky, A. Immunity (2000) [Pubmed]
  2. Monoclonal immunoglobulin A antibody directed against serotype-specific epitope of Shigella flexneri lipopolysaccharide protects against murine experimental shigellosis. Phalipon, A., Kaufmann, M., Michetti, P., Cavaillon, J.M., Huerre, M., Sansonetti, P., Kraehenbuhl, J.P. J. Exp. Med. (1995) [Pubmed]
  3. Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine. Phalipon, A., Costachel, C., Grandjean, C., Thuizat, A., Guerreiro, C., Tanguy, M., Nato, F., Vulliez-Le Normand, B., Bélot, F., Wright, K., Marcel-Peyre, V., Sansonetti, P.J., Mulard, L.A. J. Immunol. (2006) [Pubmed]
  4. Furazolidone versus ampicillin in the treatment of traveler's diarrhea. DuPont, H.L., Ericsson, C.D., Galindo, E., Wood, L.V., Morgan, D., Bitsura, J.A., Mendiola, J.G. Antimicrob. Agents Chemother. (1984) [Pubmed]
  5. Increased nitrite and nitrate concentrations in sera and urine of patients with cholera or shigellosis. Rabbani, G.H., Islam, S., Chowdhury, A.K., Mitra, A.K., Miller, M.J., Fuchs, G. Am. J. Gastroenterol. (2001) [Pubmed]
  6. Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers' diarrhea. Johnson, P.C., Ericsson, C.D., DuPont, H.L., Morgan, D.R., Bitsura, J.A., Wood, L.V. JAMA (1986) [Pubmed]
  7. Single-dose tetracycline therapy for shigellosis in adults. Pickering, L.K., DuPont, H.L., Olarte, J. JAMA (1978) [Pubmed]
  8. Trimethoprim-sulfamethoxazole therapy for shigellosis. Nelson, J.D., Kusmiesz, H., Jackson, L.H., Woodman, E. JAMA (1976) [Pubmed]
  9. Antimicrobial resistance of Shigellae isolated in Michigan. Gordon, R.C., Thompson, T.R., Carlson, W., Dyke, J.W., Stevens, L.I. JAMA (1975) [Pubmed]
  10. Single-dose ciprofloxacin for shigellosis. Williams, H.M., Richards, J. Lancet (1990) [Pubmed]
  11. Treatment of shigellosis: V. Comparison of azithromycin and ciprofloxacin. A double-blind, randomized, controlled trial. Khan, W.A., Seas, C., Dhar, U., Salam, M.A., Bennish, M.L. Ann. Intern. Med. (1997) [Pubmed]
  12. Doxycycline prophylaxis for shigellosis. Ben-Yehuda, O., Cohen, D., Alkan, M., Greenbaum, A., Jelin, N., Steinherz, R. Arch. Intern. Med. (1990) [Pubmed]
  13. Predictors of serum retinol in children with shigellosis. Mitra, A.K., Alvarez, J.O., Wahed, M.A., Fuchs, G.J., Stephensen, C.B. Am. J. Clin. Nutr. (1998) [Pubmed]
  14. Fecal steroids in diarrhea. I. Acute shigellosis. Huang, C.T., Woodward, W.E., Hornick, R.B., Rodriguez, J.T., Nichols, B.L. Am. J. Clin. Nutr. (1976) [Pubmed]
  15. Extracellular transport of VirG protein in Shigella. Suzuki, T., Lett, M.C., Sasakawa, C. J. Biol. Chem. (1995) [Pubmed]
  16. Local entrapment of interferon gamma in the recovery from Shigella dysenteriae type 1 infection. Raqib, R., Ljungdahl, A., Lindberg, A.A., Andersson, U., Andersson, J. Gut (1996) [Pubmed]
  17. Human monocytes kill Shigella flexneri but then die by apoptosis associated with suppression of proinflammatory cytokine production. Hathaway, L.J., Griffin, G.E., Sansonetti, P.J., Edgeworth, J.D. Infect. Immun. (2002) [Pubmed]
  18. Natural immunity to shigellosis in two groups with different previous risks of exposure to Shigella is only partly expressed by serum antibodies to lipopolysaccharide. Cohen, D., Green, M.S., Block, C., Slepon, R., Lerman, Y. J. Infect. Dis. (1992) [Pubmed]
  19. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Moss, J.E., Fisher, P.E., Vick, B., Groisman, E.A., Zychlinsky, A. Cell. Microbiol. (2000) [Pubmed]
  20. Presence of specific immunoglobulin A-secreting cells in peripheral blood after natural infection with Shigella sonnei. Orr, N., Robin, G., Lowell, G., Cohen, D. J. Clin. Microbiol. (1992) [Pubmed]
  21. Macrophage apoptosis in microbial infections. Hilbi, H., Zychlinsky, A., Sansonetti, P.J. Parasitology (1997) [Pubmed]
  22. Peripheral blood neutrophil responses in children with shigellosis. Azim, T., Islam, L.N., Halder, R.C., Hamadani, J., Khanum, N., Sarker, M.S., Salam, M.A., Albert, M.J. Clin. Diagn. Lab. Immunol. (1995) [Pubmed]
  23. The effect of dietary protein supplementation on insulin-like growth factors (IGFs) and IGF-binding proteins in children with shigellosis. Pucilowska, J.B., Davenport, M.L., Kabir, I., Clemmons, D.R., Thissen, J.P., Butler, T., Underwood, L.E. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  24. Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2. Raqib, R., Ekberg, C., Sharkar, P., Bardhan, P.K., Zychlinsky, A., Sansonetti, P.J., Andersson, J. Infect. Immun. (2002) [Pubmed]
  25. Characteristics of Shigella sonnei infection of volunteers: signs, symptoms, immune responses, changes in selected cytokines and acute-phase substances. Munoz, C., Baqar, S., van de Verg, L., Thupari, J., Goldblum, S., Olson, J.G., Taylor, D.N., Heresi, G.P., Murphy, J.R. Am. J. Trop. Med. Hyg. (1995) [Pubmed]
  26. Blockade of CD14 aggravates experimental shigellosis. Wennerås, C., Ave, P., Huerre, M., Arondel, J., Ulevitch, R., Mathison, J., Sansonetti, P. J. Endotoxin Res. (2001) [Pubmed]
  27. Induction of mRNA for tumor necrosis factor-alpha and interleukin-1 beta in mice brain, spleen and liver in an animal model of Shigella-related seizures. Nofech-Mozes, Y., Yuhas, Y., Kaminsky, E., Weizman, A., Ashkenazi, S. Isr. Med. Assoc. J. (2000) [Pubmed]
  28. Double-blind vaccine-controlled randomised efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults. Cohen, D., Ashkenazi, S., Green, M.S., Gdalevich, M., Robin, G., Slepon, R., Yavzori, M., Orr, N., Block, C., Ashkenazi, I., Shemer, J., Taylor, D.N., Hale, T.L., Sadoff, J.C., Pavliakova, D., Schneerson, R., Robbins, J.B. Lancet (1997) [Pubmed]
  29. A randomized, double-blind study comparing cefixime and trimethoprim-sulfamethoxazole in the treatment of childhood shigellosis. Ashkenazi, S., Amir, J., Waisman, Y., Rachmel, A., Garty, B.Z., Samra, Z., Varsano, I., Nitzan, M. J. Pediatr. (1993) [Pubmed]
  30. Lack of reactivation of shigellosis in naturally infected enrofloxacin-treated cynomolgus monkeys after exogenous immunosuppression. Black-Schultz, L., Coatney, R.W., Warnick, C.L., Swif, B. Lab. Anim. Sci. (1997) [Pubmed]
  31. Single dose vitamin A treatment in acute shigellosis in Bangladesh children: randomised double blind controlled trial. Hossain, S., Biswas, R., Kabir, I., Sarker, S., Dibley, M., Fuchs, G., Mahalanabis, D. BMJ (1998) [Pubmed]
  32. Shigella-specific IgA in saliva of children with bacillary dysentery. Schultsz, C., Qadri, F., Hossain, S.A., Ahmed, F., Ciznar, I. FEMS microbiology immunology. (1992) [Pubmed]
WikiGenes - Universities