Disease relevance of hmw3

• The Mycoplasma pneumoniae hmw3 gene was sequenced and its gene product was characterized with the goal of elucidating the functional role of HMW3 as an accessory component in cytadherence [1].
• We have cloned the gene encoding the Mycoplasma pneumoniae cytadherence-accessory protein HMW3 into Escherichia coli to study its phase-variable expression [2].

High impact information on hmw3

• However, the hmw1 and hmw3 genes were transcribed and translated at wild-type levels in hmw2 mutants [3].
• A total of 2,016 bp of the hmw3 locus was sequenced, revealing an open reading frame large enough to encode a 672-amino-acid protein with a molecular weight of 73,725 [1].
• Nucleotide sequence analysis reveals novel features of the phase-variable cytadherence accessory protein HMW3 of Mycoplasma pneumoniae [1].
• Characterization of a Mycoplasma pneumoniae hmw3 mutant: implications for attachment organelle assembly [4].
• Genetic loci for deoC, rrn, hmw3, and the P1 gene were identified by using cloned DNA to probe ApaI restriction fragment profiles [5].

Biological context of hmw3

• However, hmw3 was flanked by upstream and downstream open reading frames [1].

References