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Gene Review:

argA - N-acetylglutamate synthase

Pseudomonas aeruginosa PAO1

Haas, D. et al., Früh, H. et al., Hass, D. et al., Holloway, B.W.

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Disease relevance of argA

N-Acetylglutamate synthase, the enzyme which replenishes the cycle of acetylated intermediates in ornithine synthesis of Pseudomonas, appears to be essential for arginine synthesis since argA mutants showed no growth on unsupplemented minimal medium [1].

High impact information on argA

The suppressor locus arcB (Su) was mapped by transduction between hisII and argA [2].
The chromosomal segment includes the markers argA, argB, argH, and lys-12 [3].
Its localization in the periplasmic space explains the inability of P. aeruginosa argA mutants to grow on N-acetylglutamate, which is utilized by the wild-type as a carbon and nitrogen source [4].

References

The genetic organization of arginine biosynthesis in Pseudomonas aeruginosa. Haas, D., Holloway, B.W., Schamböck, A., Leisinger, T. Mol. Gen. Genet. (1977) [Pubmed]
Genetic and physiological characterization of Pseudomonas aeruginosa mutants affected in the catabolic ornithine carbamoyltransferase. Hass, D., Evans, R., Mercenier, A., Simon, J.P., Stalon, V. J. Bacteriol. (1979) [Pubmed]
Isolation and characterization of an R' plasmid in Pseudomonas aeruginosa. Holloway, B.W. J. Bacteriol. (1978) [Pubmed]
Properties and localization of N-acetylglutamate deacetylase from Pseudomonas aeruginosa. Früh, H., Leisinger, T. J. Gen. Microbiol. (1981) [Pubmed]

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