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Gene Review

argA  -  N-acetylglutamate synthase

Pseudomonas aeruginosa PAO1

 
 
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Disease relevance of argA

 

High impact information on argA

  • The suppressor locus arcB (Su) was mapped by transduction between hisII and argA [2].
  • The chromosomal segment includes the markers argA, argB, argH, and lys-12 [3].
  • Its localization in the periplasmic space explains the inability of P. aeruginosa argA mutants to grow on N-acetylglutamate, which is utilized by the wild-type as a carbon and nitrogen source [4].

References

  1. The genetic organization of arginine biosynthesis in Pseudomonas aeruginosa. Haas, D., Holloway, B.W., Schamböck, A., Leisinger, T. Mol. Gen. Genet. (1977) [Pubmed]
  2. Genetic and physiological characterization of Pseudomonas aeruginosa mutants affected in the catabolic ornithine carbamoyltransferase. Hass, D., Evans, R., Mercenier, A., Simon, J.P., Stalon, V. J. Bacteriol. (1979) [Pubmed]
  3. Isolation and characterization of an R' plasmid in Pseudomonas aeruginosa. Holloway, B.W. J. Bacteriol. (1978) [Pubmed]
  4. Properties and localization of N-acetylglutamate deacetylase from Pseudomonas aeruginosa. Früh, H., Leisinger, T. J. Gen. Microbiol. (1981) [Pubmed]
 
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