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Gene Review:

prtR - transcriptional regulator PrtR

Pseudomonas aeruginosa PAO1

Wu, W. et al., Matsui, H. et al.

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Disease relevance of prtR

In a search for regulatory genes of the type III secretion system (TTSS) in Pseudomonas aeruginosa, transposon (Tn5) insertional mutants of the prtR gene were found defective in the TTSS [1].
The prtR gene represses the expression of the prtN gene, and its product, predicted from the nucleotide sequence, has a structure characteristic of phage repressors and seems to be inactivated by the RecA protein activated by DNA damage [2].

High impact information on prtR

To identify the PrtR-regulated TTSS repressor, another round of Tn mutagenesis was carried out in the background of a prtR/prtN double mutant [1].

References

PtrB of Pseudomonas aeruginosa suppresses the type III secretion system under the stress of DNA damage. Wu, W., Jin, S. J. Bacteriol. (2005) [Pubmed]
Regulation of pyocin genes in Pseudomonas aeruginosa by positive (prtN) and negative (prtR) regulatory genes. Matsui, H., Sano, Y., Ishihara, H., Shinomiya, T. J. Bacteriol. (1993) [Pubmed]

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