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Gene Review:

prtN - transcriptional regulator PrtN

Pseudomonas aeruginosa PAO1

Matsui, H. et al., Michel-Briand, Y. et al., Wu, W. et al.

Michel-Briand, Baysse,

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Disease relevance of prtN

The prtR gene represses the expression of the prtN gene, and its product, predicted from the nucleotide sequence, has a structure characteristic of phage repressors and seems to be inactivated by the RecA protein activated by DNA damage [1].
Regulation of pyocin genes in Pseudomonas aeruginosa by positive (prtN) and negative (prtR) regulatory genes [1].

High impact information on prtN

To identify the PrtR-regulated TTSS repressor, another round of Tn mutagenesis was carried out in the background of a prtR/prtN double mutant [2].
The prtN gene activates the expression of various pyocin genes, probably by the interaction of its product with the DNA sequences conserved in the 5' noncoding regions of the pyocin genes [1].
The synthesis of pyocins starts when a mutagen increases the expression of the recA gene and activates the RecA protein, which cleaves the repressor PrtR, liberating the expression of the protein activator gene prtN [3].

References

Regulation of pyocin genes in Pseudomonas aeruginosa by positive (prtN) and negative (prtR) regulatory genes. Matsui, H., Sano, Y., Ishihara, H., Shinomiya, T. J. Bacteriol. (1993) [Pubmed]
PtrB of Pseudomonas aeruginosa suppresses the type III secretion system under the stress of DNA damage. Wu, W., Jin, S. J. Bacteriol. (2005) [Pubmed]
The pyocins of Pseudomonas aeruginosa. Michel-Briand, Y., Baysse, C. Biochimie (2002) [Pubmed]

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