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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DPM2  -  dolichyl-phosphate mannosyltransferase...

Homo sapiens

Synonyms: DPM synthase subunit 2, Dolichol phosphate-mannose biosynthesis regulatory protein, Dolichol-phosphate mannose synthase subunit 2, MGC111193, MGC21559, ...
 
 
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High impact information on DPM2

  • The stability of DPM3 was dependent upon DPM2 [1].
  • Mammalian dolichol-phosphate-mannose (DPM) synthase has three subunits, DPM1, DPM2, and DPM3 [2].
  • A single point mutation resulting in an adversely reduced expression of DPM2 in the Lec15.1 cells [3].
  • The divergent 5' ends of DPM2 mRNAs originate from the alternative splicing of two adjacent introns: characterization of the hamster DPM2 gene [2].
  • Moreover, mutant DPM2 cDNA expressed a drastically reduced amount of DPM2 protein and poorly corrects the Lec15.1 cell phenotype when compared with wild type CHO DPM2 cDNA (G(29) form) [3].
 

Associations of DPM2 with chemical compounds

  • In contrast, Lec15.1 cells were found to have a single point mutation G29A within the coding region of the DPM2 gene, resulting in a glycine to glutamic acid change in amino acid residue 10 of the peptide [3].

References

  1. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. Maeda, Y., Tanaka, S., Hino, J., Kangawa, K., Kinoshita, T. EMBO J. (2000) [Pubmed]
  2. The divergent 5' ends of DPM2 mRNAs originate from the alternative splicing of two adjacent introns: characterization of the hamster DPM2 gene. Pu, L., Scocca, J.R., Walker, B.K., Krag, S.S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. A single point mutation resulting in an adversely reduced expression of DPM2 in the Lec15.1 cells. Pu, L., Scocca, J.R., Walker, B.K., Krag, S.S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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