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Gene Review

DPM3  -  dolichyl-phosphate mannosyltransferase...

Homo sapiens

Synonyms: DPM synthase subunit 3, Dolichol-phosphate mannose synthase subunit 3, Dolichol-phosphate mannosyltransferase subunit 3, Dolichyl-phosphate beta-D-mannosyltransferase subunit 3, MGC125904, ...
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Disease relevance of DPM3


High impact information on DPM3

  • The third subunit, DPM3, comprises 92 amino acids associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion [3].
  • The stability of DPM3 was dependent upon DPM2 [3].
  • A coiled-coil domain near the C terminus of DPM3 was important for tethering DPM1, the catalytic subunit of the enzyme, to the endoplasmic reticulum membrane and, therefore, was critical for enzyme activity [4].
  • CHO2.38 cells were negative for GPI-anchored proteins, and microsomes from these cells showed no detectable DPM synthase activity, indicating that DPM3 is an essential component of this enzyme [4].
  • The prostin-1 gene, conserved through phylogeny, is induced by androgen in LNCaP cells and encodes a 92 amino acid protein [5].

Chemical compound and disease context of DPM3


Biological context of DPM3


Associations of DPM3 with chemical compounds


Regulatory relationships of DPM3

  • Recombinant prostin readily activates the precursor of PSA (pro-PSA) by cleavage of the amino terminal Arg(7)-Ile(8) peptide bond [8].

Other interactions of DPM3

  • The zymogen, with a molecular mass of 28 kDa, was readily activated by agarose-immobilized trypsin to generate prostin, a serine protease, which cleaves the chromogenic substrate (N-benzoyl-L-Ile-L-Glu-L-Gly-L-Arg-p-nitroaniline hydrochloride) (S-2222) [8].
  • Significant relationships were observed inversely between the total prostin dose and Bishop score (R(2)=0.33; P=0.002), between the total prostin dose and latent phase (R(2)=0.54; P=0.000009) and between Bishop score and the fibronectin levels (R(2)=0.19; P<0.01) [13].

Analytical, diagnostic and therapeutic context of DPM3


  1. Hemodynamic and oxygen transport effects of prostaglandin E1 in patients with adult respiratory distress syndrome. Appel, P.L., Shoemaker, W.C. Crit. Care Med. (1984) [Pubmed]
  2. The use of 15 methyl F2 alpha prostaglandin (Prostin 15M) for the control of postpartum hemorrhage. Buttino, L., Garite, T.J. American journal of perinatology. (1986) [Pubmed]
  3. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. Maeda, Y., Tanaka, S., Hino, J., Kangawa, K., Kinoshita, T. EMBO J. (2000) [Pubmed]
  4. DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. Ashida, H., Maeda, Y., Kinoshita, T. J. Biol. Chem. (2006) [Pubmed]
  5. Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion. Manos, E.J., Kim, M.L., Kassis, J., Chang, P.Y., Wells, A., Jones, D.A. Oncogene (2001) [Pubmed]
  6. Induction of abortion in the second trimester of pregnancy by intramuscular 15-methyl prostaglandin F 2 alpha (Prostin 15M). Novak-Antolic, Z., Assejev, V. Clinical and experimental obstetrics & gynecology. (1982) [Pubmed]
  7. Induction of abortion by intramuscular administration of (15S)-15-methyl PGF2 alpha. An overview of 815 cases. Schwallie, P.C., Lamborn, K.R. The Journal of reproductive medicine. (1979) [Pubmed]
  8. Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR. Takayama, T.K., Carter, C.A., Deng, T. Biochemistry (2001) [Pubmed]
  9. A multiclinic, placebo-controlled, double-blind study of prostaglandin E1 in Raynaud's syndrome. Mohrland, J.S., Porter, J.M., Smith, E.A., Belch, J., Simms, M.H. Ann. Rheum. Dis. (1985) [Pubmed]
  10. Quantitative determination of alprostadil (PGE) in bulk drug and pharmaceutical formulations by high-performance liquid chromatography. Zoutendam, P.H., Bowman, P.B., Ryan, T.M., Rumph, J.L. J. Chromatogr. (1984) [Pubmed]
  11. Recurrent inversion of the puerperal uterus managed with 15(s)-15-methyl prostaglandin F2 alpha and uterine packing. Heyl, P.S., Stubblefield, P.G., Phillippe, M. Obstetrics and gynecology. (1984) [Pubmed]
  12. Oral oxytocics for induction of labor. A randomized study of prostaglandin E2 tablets and demoxytocin resoriblets. Westergaard, J.G., Lange, A.P., Pedersen, G.T., Secher, N.J. Acta obstetricia et gynecologica Scandinavica. (1983) [Pubmed]
  13. Quantitative foetal fibronectin as a predictor of successful induction of labour in post-date pregnancies. Ojutiku, D., Jones, G., Bewley, S. Eur. J. Obstet. Gynecol. Reprod. Biol. (2002) [Pubmed]
  14. Quantitative determination of prostaglandins A1 and B1 in alprostadil (PGE1) by high-performance liquid chromatography. Zoutendam, P.H., Bowman, P.B., Rumph, J.L., Ryan, T.M. J. Chromatogr. (1984) [Pubmed]
  15. Amniotic fluid embolism: a case report and review. Fletcher, S.J., Parr, M.J. Resuscitation. (2000) [Pubmed]
  16. Is propess a better method of induction of labour in nulliparous women. Mukhopadhyay, M., Lim, K.J., Fairlie, F.M. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. (2002) [Pubmed]
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