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DPM3  -  dolichyl-phosphate mannosyltransferase...

Homo sapiens

Synonyms: DPM synthase subunit 3, Dolichol-phosphate mannose synthase subunit 3, Dolichol-phosphate mannosyltransferase subunit 3, Dolichyl-phosphate beta-D-mannosyltransferase subunit 3, MGC125904, ...
 
 
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Disease relevance of DPM3

 

High impact information on DPM3

  • The third subunit, DPM3, comprises 92 amino acids associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion [3].
  • The stability of DPM3 was dependent upon DPM2 [3].
  • A coiled-coil domain near the C terminus of DPM3 was important for tethering DPM1, the catalytic subunit of the enzyme, to the endoplasmic reticulum membrane and, therefore, was critical for enzyme activity [4].
  • CHO2.38 cells were negative for GPI-anchored proteins, and microsomes from these cells showed no detectable DPM synthase activity, indicating that DPM3 is an essential component of this enzyme [4].
  • The prostin-1 gene, conserved through phylogeny, is induced by androgen in LNCaP cells and encodes a 92 amino acid protein [5].
 

Chemical compound and disease context of DPM3

 

Biological context of DPM3

 

Associations of DPM3 with chemical compounds

 

Regulatory relationships of DPM3

  • Recombinant prostin readily activates the precursor of PSA (pro-PSA) by cleavage of the amino terminal Arg(7)-Ile(8) peptide bond [8].
 

Other interactions of DPM3

  • The zymogen, with a molecular mass of 28 kDa, was readily activated by agarose-immobilized trypsin to generate prostin, a serine protease, which cleaves the chromogenic substrate (N-benzoyl-L-Ile-L-Glu-L-Gly-L-Arg-p-nitroaniline hydrochloride) (S-2222) [8].
  • Significant relationships were observed inversely between the total prostin dose and Bishop score (R(2)=0.33; P=0.002), between the total prostin dose and latent phase (R(2)=0.54; P=0.000009) and between Bishop score and the fibronectin levels (R(2)=0.19; P<0.01) [13].
 

Analytical, diagnostic and therapeutic context of DPM3

References

  1. Hemodynamic and oxygen transport effects of prostaglandin E1 in patients with adult respiratory distress syndrome. Appel, P.L., Shoemaker, W.C. Crit. Care Med. (1984) [Pubmed]
  2. The use of 15 methyl F2 alpha prostaglandin (Prostin 15M) for the control of postpartum hemorrhage. Buttino, L., Garite, T.J. American journal of perinatology. (1986) [Pubmed]
  3. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. Maeda, Y., Tanaka, S., Hino, J., Kangawa, K., Kinoshita, T. EMBO J. (2000) [Pubmed]
  4. DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. Ashida, H., Maeda, Y., Kinoshita, T. J. Biol. Chem. (2006) [Pubmed]
  5. Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion. Manos, E.J., Kim, M.L., Kassis, J., Chang, P.Y., Wells, A., Jones, D.A. Oncogene (2001) [Pubmed]
  6. Induction of abortion in the second trimester of pregnancy by intramuscular 15-methyl prostaglandin F 2 alpha (Prostin 15M). Novak-Antolic, Z., Assejev, V. Clinical and experimental obstetrics & gynecology. (1982) [Pubmed]
  7. Induction of abortion by intramuscular administration of (15S)-15-methyl PGF2 alpha. An overview of 815 cases. Schwallie, P.C., Lamborn, K.R. The Journal of reproductive medicine. (1979) [Pubmed]
  8. Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR. Takayama, T.K., Carter, C.A., Deng, T. Biochemistry (2001) [Pubmed]
  9. A multiclinic, placebo-controlled, double-blind study of prostaglandin E1 in Raynaud's syndrome. Mohrland, J.S., Porter, J.M., Smith, E.A., Belch, J., Simms, M.H. Ann. Rheum. Dis. (1985) [Pubmed]
  10. Quantitative determination of alprostadil (PGE) in bulk drug and pharmaceutical formulations by high-performance liquid chromatography. Zoutendam, P.H., Bowman, P.B., Ryan, T.M., Rumph, J.L. J. Chromatogr. (1984) [Pubmed]
  11. Recurrent inversion of the puerperal uterus managed with 15(s)-15-methyl prostaglandin F2 alpha and uterine packing. Heyl, P.S., Stubblefield, P.G., Phillippe, M. Obstetrics and gynecology. (1984) [Pubmed]
  12. Oral oxytocics for induction of labor. A randomized study of prostaglandin E2 tablets and demoxytocin resoriblets. Westergaard, J.G., Lange, A.P., Pedersen, G.T., Secher, N.J. Acta obstetricia et gynecologica Scandinavica. (1983) [Pubmed]
  13. Quantitative foetal fibronectin as a predictor of successful induction of labour in post-date pregnancies. Ojutiku, D., Jones, G., Bewley, S. Eur. J. Obstet. Gynecol. Reprod. Biol. (2002) [Pubmed]
  14. Quantitative determination of prostaglandins A1 and B1 in alprostadil (PGE1) by high-performance liquid chromatography. Zoutendam, P.H., Bowman, P.B., Rumph, J.L., Ryan, T.M. J. Chromatogr. (1984) [Pubmed]
  15. Amniotic fluid embolism: a case report and review. Fletcher, S.J., Parr, M.J. Resuscitation. (2000) [Pubmed]
  16. Is propess a better method of induction of labour in nulliparous women. Mukhopadhyay, M., Lim, K.J., Fairlie, F.M. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. (2002) [Pubmed]
 
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