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pchC  -  pyochelin biosynthetic protein PchC

Pseudomonas aeruginosa PAO1

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High impact information on pchC

  • In vivo, this analog strongly interfered with Dha and pyochelin formation in a pchC deletion mutant but affected production of these metabolites only slightly in the wild type [1].
  • Exogenously supplied cysteine overcame the negative effect of a pchC mutation to a large extent, whereas addition of salicylate did not [1].
  • The 2.5-kb region upstream of the salicylate biosynthetic genes pchBA was sequenced and found to contain two additional, contiguous genes, pchD and pchC, having the same orientation [2].


  1. PchC thioesterase optimizes nonribosomal biosynthesis of the peptide siderophore pyochelin in Pseudomonas aeruginosa. Reimmann, C., Patel, H.M., Walsh, C.T., Haas, D. J. Bacteriol. (2004) [Pubmed]
  2. Biosynthesis of pyochelin and dihydroaeruginoic acid requires the iron-regulated pchDCBA operon in Pseudomonas aeruginosa. Serino, L., Reimmann, C., Visca, P., Beyeler, M., Chiesa, V.D., Haas, D. J. Bacteriol. (1997) [Pubmed]
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