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pchD  -  pyochelin biosynthesis protein PchD

Pseudomonas aeruginosa PAO1

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High impact information on pchD

  • Transcription of pchD started at tandemly arranged promoters, which overlapped with two Fur boxes (binding sites for the ferric uptake regulator) and the promoter of the divergently transcribed pchR gene encoding an activator of pyochelin biosynthesis [1].
  • The 2.5-kb region upstream of the salicylate biosynthetic genes pchBA was sequenced and found to contain two additional, contiguous genes, pchD and pchC, having the same orientation [1].
  • Inactivation of the chromosomal pchD gene by insertion of the transcription and translation stop element omega Sm/Sp abolished the production of Dha and pyochelin, implying that PchD-mediated activation of salicylate may be a common first step in the synthesis of both metabolites [1].


  1. Biosynthesis of pyochelin and dihydroaeruginoic acid requires the iron-regulated pchDCBA operon in Pseudomonas aeruginosa. Serino, L., Reimmann, C., Visca, P., Beyeler, M., Chiesa, V.D., Haas, D. J. Bacteriol. (1997) [Pubmed]
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