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Gene Review:

pfeR - two-component response regulator PfeR

Pseudomonas aeruginosa PAO1

Dean, C.R. et al., Dean, C.R. et al.

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High impact information on pfeR

The predicted products of pfeR and pfeS (molecular weight 26,796 and 50,597, respectively) exhibited a high degree of homology to response-regulator and sensor components, respectively, of the superfamily of prokaryotic environmentally responsive protein pairs [1].
Furthermore, a pfeR mutant obtained by in vitro mutagenesis and gene replacement failed to express PfeA despite the presence of enterobactin in the culture medium [1].
A pfeR knockout mutant failed to demonstrate enterobactin-inducible expression of a pfeA-lacZ fusion, indicating that PfeR acts at the level of pfeA gene expression [2].
A region showing homology to the consensus binding sequence for the global iron repressor Fur was identified upstream of pfeR, suggesting that the pfeRS operon is iron regulated [2].

Biological context of pfeR

Nucleotide sequencing of a 2.5 kilobase pair (kb) region of DNA immediately upstream of pfeA revealed two open reading frames (ORFs), pfeR and pfeS, which appeared to comprise an operon [1].

References

Expression of the ferric enterobactin receptor (PfeA) of Pseudomonas aeruginosa: involvement of a two-component regulatory system. Dean, C.R., Poole, K. Mol. Microbiol. (1993) [Pubmed]
PfeR, an enterobactin-responsive activator of ferric enterobactin receptor gene expression in Pseudomonas aeruginosa. Dean, C.R., Neshat, S., Poole, K. J. Bacteriol. (1996) [Pubmed]

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