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Gene Review

fabG1  -  3-oxoacyl-ACP reductase FabG1

Mycobacterium tuberculosis H37Rv

 
 
 
 
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High impact information on fabG1

  • In this study, 52 epidemiologically unrelated clinical INH-resistant M. tuberculosis isolates collected in Australia were screened for mutations at katG codon 315 and the fabG1-inhA regulatory region [1].
  • The katG S315T substitution and fabG1-inhA -15 C-to-T mutation were identified in 34 and 13 of the 52 INH-resistant isolates, respectively, and none of the INH-sensitive isolates [1].

References

  1. Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates collected in Australia. Lavender, C., Globan, M., Sievers, A., Billman-Jacobe, H., Fyfe, J. Antimicrob. Agents Chemother. (2005) [Pubmed]
 
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