Gene Review:
inhA - enoyl-ACP reductase
Mycobacterium tuberculosis CDC1551
- Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid. Argyrou, A., Vetting, M.W., Aladegbami, B., Blanchard, J.S. Nat. Struct. Mol. Biol. (2006)
- Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis. Larsen, M.H., Vilchèze, C., Kremer, L., Besra, G.S., Parsons, L., Salfinger, M., Heifets, L., Hazbon, M.H., Alland, D., Sacchettini, J.C., Jacobs, W.R. Mol. Microbiol. (2002)
- Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes. Poletto, S.S., da Fonseca, I.O., de Carvalho, L.P., Basso, L.A., Santos, D.S. Protein Expr. Purif. (2004)
- Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis. Wilson, T.M., de Lisle, G.W., Collins, D.M. Mol. Microbiol. (1995)
- Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis. Hazbón, M.H., Brimacombe, M., Bobadilla del Valle, M., Cavatore, M., Guerrero, M.I., Varma-Basil, M., Billman-Jacobe, H., Lavender, C., Fyfe, J., García-García, L., León, C.I., Bose, M., Chaves, F., Murray, M., Eisenach, K.D., Sifuentes-Osornio, J., Cave, M.D., Ponce de León, A., Alland, D. Antimicrob. Agents Chemother. (2006)
- Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates collected in Australia. Lavender, C., Globan, M., Sievers, A., Billman-Jacobe, H., Fyfe, J. Antimicrob. Agents Chemother. (2005)
- ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Morlock, G.P., Metchock, B., Sikes, D., Crawford, J.T., Cooksey, R.C. Antimicrob. Agents Chemother. (2003)
- Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. Quémard, A., Sacchettini, J.C., Dessen, A., Vilcheze, C., Bittman, R., Jacobs, W.R., Blanchard, J.S. Biochemistry (1995)
- Performance of the Genotype MTBDR Line Probe Assay for Detection of Resistance to Rifampin and Isoniazid in Strains of Mycobacterium tuberculosis with Low- and High-Level Resistance. Brossier, F., Veziris, N., Truffot-Pernot, C., Jarlier, V., Sougakoff, W. J. Clin. Microbiol. (2006)
- Genotypic Analysis of Multidrug-Resistant Mycobacterium tuberculosis Isolates Recovered From Central China. Zhang, S.L., Qi, H., Qiu, D.L., Li, D.X., Zhang, J., Du, C.M., Wang, G.B., Yang, Z.R., Sun, Q. Biochem. Genet. (2007)
- Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis. Mdluli, K., Sherman, D.R., Hickey, M.J., Kreiswirth, B.N., Morris, S., Stover, C.K., Barry, C.E. J. Infect. Dis. (1996)
- Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis. Morris, S., Bai, G.H., Suffys, P., Portillo-Gomez, L., Fairchok, M., Rouse, D. J. Infect. Dis. (1995)
- Mycobacterium tuberculosis genes induced during infection of human macrophages. Dubnau, E., Fontán, P., Manganelli, R., Soares-Appel, S., Smith, I. Infect. Immun. (2002)
- Genomic mutations in the katG, inhA and aphC genes are useful for the prediction of isoniazid resistance in Mycobacterium tuberculosis isolates from Kwazulu Natal, South Africa. Kiepiela, P., Bishop, K.S., Smith, A.N., Roux, L., York, D.F. Tuber. Lung Dis. (2000)
- Mutations prevalent among rifampin- and isoniazid-resistant Mycobacterium tuberculosis isolates from a hospital in Vietnam. Caws, M., Duy, P.M., Tho, D.Q., Lan, N.T., Hoa, D.V., Farrar, J. J. Clin. Microbiol. (2006)
- The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance. Banerjee, A., Sugantino, M., Sacchettini, J.C., Jacobs, W.R. Microbiology (Reading, Engl.) (1998)
- Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis. Vilchèze, C., Morbidoni, H.R., Weisbrod, T.R., Iwamoto, H., Kuo, M., Sacchettini, J.C., Jacobs, W.R. J. Bacteriol. (2000)
- katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients. Marttila, H.J., Soini, H., Huovinen, P., Viljanen, M.K. Antimicrob. Agents Chemother. (1996)