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Gene Review:

mgtA - GDP-mannose-dependent alpha...

Mycobacterium tuberculosis H37Rv

Schaeffer, M.L. et al.

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Disease relevance of pimB

Partially purified recombinant PimB protein from Escherichia coli or membranes from M. smegmatis overexpressing the pimB gene were used in cell-free assays to show that PimB catalyzes the formation of triacylphosphatidylinositol dimannoside from GDP-mannose and triacylphosphatidylinositol monomannoside [1].
The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis [1].

High impact information on pimB

This strategy led to the identification of pimB, whose deduced amino acid sequence shows similarity to mannosyltransferases and other glycosyltransferases [1].

References

The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis. Schaeffer, M.L., Khoo, K.H., Besra, G.S., Chatterjee, D., Brennan, P.J., Belisle, J.T., Inamine, J.M. J. Biol. Chem. (1999) [Pubmed]

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