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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

mshA  -  D-inositol 3-phosphate glycosyltransferase

Mycobacterium tuberculosis H37Rv

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Disease relevance of Rv0486


High impact information on Rv0486

  • Thus, MT1671 is the mannosyltransferase involved in deposition of the first of the mannose residues on the non-reducing arabinan termini and the basis of much of the interaction between the tubercle bacillus and the host cell [2].
  • The ability of this mutant to synthesize the PimA mannosyltransferase was dependent on the presence of a functional copy of the pimA gene carried on a temperature-sensitive rescue plasmid [3].
  • The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis [4].
  • The biosynthesis of lipoarabinomannan (LAM), a key mycobacterial lipoglycan that has been implicated in numerous immunoregulatory functions, was examined utilizing D-mannosamine (ManN) as a tool to identify mannosyltransferase genes involved in LAM synthesis [4].
  • The mannosyltransferase activity was localized within both isolated membranes and a P60 cell wall fraction prepared from the rapidly growing mycobacterial strain, Mycobacterium smegmatis [5].

Chemical compound and disease context of Rv0486


Biological context of Rv0486

  • We examined the function of the pimA (Rv2610c) gene, located in the vicinity of the phosphatidylinositol synthase gene in the genomes of Mycobacterium tuberculosis and Mycobacterium smegmatis, which encodes a putative mannosyltransferase involved in the early steps of phosphatidylinositol mannoside synthesis [3].


  1. The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). Newton, G.L., Koledin, T., Gorovitz, B., Rawat, M., Fahey, R.C., Av-Gay, Y. J. Bacteriol. (2003) [Pubmed]
  2. Genetic basis for the synthesis of the immunomodulatory mannose caps of lipoarabinomannan in Mycobacterium tuberculosis. Dinadayala, P., Kaur, D., Berg, S., Amin, A.G., Vissa, V.D., Chatterjee, D., Brennan, P.J., Crick, D.C. J. Biol. Chem. (2006) [Pubmed]
  3. Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria. Korduláková, J., Gilleron, M., Mikusova, K., Puzo, G., Brennan, P.J., Gicquel, B., Jackson, M. J. Biol. Chem. (2002) [Pubmed]
  4. The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis. Schaeffer, M.L., Khoo, K.H., Besra, G.S., Chatterjee, D., Brennan, P.J., Belisle, J.T., Inamine, J.M. J. Biol. Chem. (1999) [Pubmed]
  5. Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay. Cooper, H.N., Gurcha, S.S., Nigou, J., Brennan, P.J., Belisle, J.T., Besra, G.S., Young, D. Glycobiology (2002) [Pubmed]
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