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Gene Review:

Rv2719c - membrane protein

Mycobacterium tuberculosis H37Rv

Chauhan, A. et al., Dullaghan, E.M. et al.

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Disease relevance of Rv2719c

Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase [1].

High impact information on Rv2719c

Overexpression of Rv2719c in the absence of DNA damage or of antibiotic treatment also led to filamentation and reduction in viability both in broth and in macrophages indicating a correlation between Rv2719c levels and cell division [1].
A novel DNA-damage-inducible gene, Rv2719c, was identified that was divergently transcribed relative to lexA; the other three SOS boxes were found to be involved in regulating expression of this novel mycobacterial-specific gene [2].

Biological context of Rv2719c

We propose that Rv2719c is a potential regulator of M. tuberculosis cell division and that its levels, and possibly activities, are modulated under a variety of growth conditions including growth in vivo and during DNA damage, so that the assembly of FtsZ-rings, and therefore the cell division, can proceed in a regulated manner [1].

Anatomical context of Rv2719c

We showed that exposure of M. tuberculosis to DNA damaging agents, or to cephalexin, or growth of M. tuberculosis in macrophages increased cell length and sharply elevated the expression of Rv2719c, a LexA-controlled gene [1].

References

Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase. Chauhan, A., Lofton, H., Maloney, E., Moore, J., Fol, M., Madiraju, M.V., Rajagopalan, M. Mol. Microbiol. (2006) [Pubmed]
The role of multiple SOS boxes upstream of the Mycobacterium tuberculosis lexA gene--identification of a novel DNA-damage-inducible gene. Dullaghan, E.M., Brooks, P.C., Davis, E.O. Microbiology (Reading, Engl.) (2002) [Pubmed]

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