The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-00PPUT     7-[(2-amino-2-phenyl- ethanoyl)amino]-3...

Synonyms: AG-D-24454, ACMC-20mbf8, SureCN10713860, BBL013211, CTK0H2709, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cephalexin


Psychiatry related information on cephalexin


High impact information on cephalexin

  • In addition, FtsZ rings are able to assemble in newborn cells in the presence of cephalexin, suggesting that newborn cells contain a site at which FtsZ can assemble (the nascent division site) and that the transpeptidase activity of FtsI is not required for assembly of FtsZ at these sites [10].
  • A 66-year-old woman had several episodes of aseptic meningitis associated with exposure to cephalexin, cefazolin, and ceftazidime [11].
  • Expression of PEPT 1 or PEPT 2 in HeLa cells was found to induce H(+)-coupled cephalexin uptake in these cells [12].
  • We showed that exposure of M. tuberculosis to DNA damaging agents, or to cephalexin, or growth of M. tuberculosis in macrophages increased cell length and sharply elevated the expression of Rv2719c, a LexA-controlled gene [13].
  • The tus deletion strain yielded a small fraction of cells that overproduce DNA, as determined by flow cytometry after run-out chromosome replication in the presence of rifampicin and cephalexin [14].

Chemical compound and disease context of cephalexin


Biological context of cephalexin


Anatomical context of cephalexin


Associations of cephalexin with other chemical compounds


Gene context of cephalexin


Analytical, diagnostic and therapeutic context of cephalexin


  1. Cephalexin for susceptible bacteriuria in afebrile, long-term catheterized patients. Warren, J.W., Anthony, W.C., Hoopes, J.M., Muncie, H.L. JAMA (1982) [Pubmed]
  2. Cephalexin monohydrate suspension. Treatment of otitis media. McLinn, S.E., Daly, J.F., Jones, J.E. JAMA (1975) [Pubmed]
  3. Ecological impact of ampicillin and cefuroxime in neonatal units. Tullus, K., Burman, L.G. Lancet (1989) [Pubmed]
  4. Ototoxicity associated with cephalexin in two patients with renal failure. Sennesael, J., Verbeelen, D., Lauwers, S. Lancet (1982) [Pubmed]
  5. Mimicking natural evolution in metallo-beta-lactamases through second-shell ligand mutations. Tomatis, P.E., Rasia, R.M., Segovia, L., Vila, A.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Epileptogenic activity of cephalosporins in rats and their structure-activity relationship. Kamei, C., Sunami, A., Tasaka, K. Epilepsia (1983) [Pubmed]
  7. An overview of results of world-wide clinical trials with cefadroxil. Santella, P.J., Tanrisever, B., Berman, E. J. Int. Med. Res. (1978) [Pubmed]
  8. Bacterial prostatitis: treatment with carbenicillin indanyl sodium. Mobley, D.F. Investigative urology. (1981) [Pubmed]
  9. Recurrent diarrhea associated with enterotoxigenic Clostridium perfringens in 2 dogs. Weese, J.S., Greenwood, S.J., Staempfli, H.R. Can. Vet. J. (2001) [Pubmed]
  10. Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites. Pogliano, J., Pogliano, K., Weiss, D.S., Losick, R., Beckwith, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  11. Cephalosporin-induced recurrent aseptic meningitis. Creel, G.B., Hurtt, M. Ann. Neurol. (1995) [Pubmed]
  12. Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. Ganapathy, M.E., Brandsch, M., Prasad, P.D., Ganapathy, V., Leibach, F.H. J. Biol. Chem. (1995) [Pubmed]
  13. Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase. Chauhan, A., Lofton, H., Maloney, E., Moore, J., Fol, M., Madiraju, M.V., Rajagopalan, M. Mol. Microbiol. (2006) [Pubmed]
  14. A new in vivo termination function for DNA polymerase I of Escherichia coli K12. Markovitz, A. Mol. Microbiol. (2005) [Pubmed]
  15. BMY 28100, a new oral cephalosporin. Leitner, F., Pursiano, T.A., Buck, R.E., Tsai, Y.H., Chisholm, D.R., Misiek, M., Desiderio, J.V., Kessler, R.E. Antimicrob. Agents Chemother. (1987) [Pubmed]
  16. Comparative activities of cefuroxime, amoxicillin-clavulanic acid, ciprofloxacin, enoxacin, and ofloxacin against aerobic and anaerobic bacteria isolated from bite wounds. Goldstein, E.J., Citron, D.M. Antimicrob. Agents Chemother. (1988) [Pubmed]
  17. In vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, R-3746. Chin, N.X., Neu, H.C. Antimicrob. Agents Chemother. (1988) [Pubmed]
  18. Lack of in vitro efficacy of oral forms of certain cephalosporins, erythromycin, and oxacillin against Pasteurella multocida. Goldstein, E.J., Citron, D.M., Richwald, G.A. Antimicrob. Agents Chemother. (1988) [Pubmed]
  19. Diffusion of beta-lactam antibiotics through liposome membranes containing purified porins. Kobayashi, Y., Takahashi, I., Nakae, T. Antimicrob. Agents Chemother. (1982) [Pubmed]
  20. Cell division is required for resolution of dimer chromosomes at the dif locus of Escherichia coli. Steiner, W.W., Kuempel, P.L. Mol. Microbiol. (1998) [Pubmed]
  21. Cefazolin and cephalexin kinetics in continuous ambulatory peritoneal dialysis. Bunke, C.M., Aronoff, G.R., Brier, M.E., Sloan, R.S., Luft, F.C. Clin. Pharmacol. Ther. (1983) [Pubmed]
  22. Pharmacokinetics of alafosfalin, alone and in combination with cephalexin, in humans. Allen, J.G., Lees, L.J. Antimicrob. Agents Chemother. (1980) [Pubmed]
  23. The variation of catalytic efficiency of Bacillus cereus metallo-beta-lactamase with different active site metal ions. Badarau, A., Page, M.I. Biochemistry (2006) [Pubmed]
  24. Structure-activity relationship of carbacephalosporins and cephalosporins: antibacterial activity and interaction with the intestinal proton-dependent dipeptide transport carrier of Caco-2 cells. Snyder, N.J., Tabas, L.B., Berry, D.M., Duckworth, D.C., Spry, D.O., Dantzig, A.H. Antimicrob. Agents Chemother. (1997) [Pubmed]
  25. The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem. Tune, B.M., Hsu, C.Y. J. Am. Soc. Nephrol. (1990) [Pubmed]
  26. 3-day course of ofloxacin versus cefalexin in the treatment of urinary tract infections in postmenopausal women. Raz, R., Rozenfeld, S. Antimicrob. Agents Chemother. (1996) [Pubmed]
  27. Localization of multidrug transporter substrates within model membranes. Siarheyeva, A., Lopez, J.J., Glaubitz, C. Biochemistry (2006) [Pubmed]
  28. A soluble enzyme activity that attaches free diaminopimelic acid to bdelloplast peptidoglycan. Araki, Y., Ruby, E.G. Biochemistry (1988) [Pubmed]
  29. In vitro susceptibility studies with cefaclor and cephalexin. Scheld, W.M., Korzeniowski, O.M., Sande, M.A. Antimicrob. Agents Chemother. (1977) [Pubmed]
  30. Comparative pharmacokinetics of cephalexin, cefaclor, cefadroxil, and CGP 9000. Lode, H., Stahlmann, R., Koeppe, P. Antimicrob. Agents Chemother. (1979) [Pubmed]
  31. Cefixime. A review of its therapeutic efficacy in lower respiratory tract infections. Markham, A., Brogden, R.N. Drugs (1995) [Pubmed]
  32. Significance of "extravascular" protein binding for antimicrobial pharmacodynamics in an in vitro capillary model of infection. Dudley, M.N., Blaser, J., Gilbert, D., Zinner, S.H. Antimicrob. Agents Chemother. (1990) [Pubmed]
  33. Single-dose fosfomycin trometamol versus 5-day cephalexin regimen for treatment of uncomplicated lower urinary tract infections in women. Elhanan, G., Tabenkin, H., Yahalom, R., Raz, R. Antimicrob. Agents Chemother. (1994) [Pubmed]
  34. Localization of cell division protein FtsK to the Escherichia coli septum and identification of a potential N-terminal targeting domain. Yu, X.C., Tran, A.H., Sun, Q., Margolin, W. J. Bacteriol. (1998) [Pubmed]
  35. Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Luckner, P., Brandsch, M. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2005) [Pubmed]
  36. In vitro activity and beta-lactamase stability of LY163892. Pelosi, E., Fontana, R. Eur. J. Clin. Microbiol. Infect. Dis. (1988) [Pubmed]
  37. Antimicrobial agents induce monocytes to release IL-1 alpha, IL-6, and TNF, and induce lymphocytes to release IL-4 and TNF tau. Tufano, M.A., Cipollaro de l'Ero, G., Ianniello, R., Baroni, A., Galdiero, F. Immunopharmacology and immunotoxicology. (1992) [Pubmed]
  38. Evaluation in an animal model and in vitro of the combination clavulanic acid and cephalosporins against beta-lactamase producing and nonproducing Staphylococcus aureus strains. de Sá Del Fiol, F., Rocha De Mattos Filho, T., Groppo, F.C. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. (2000) [Pubmed]
  39. Prophylactic cephalexin ineffective in chronic ambulatory peritoneal dialysis. Low, D.E., Vas, S.I., Oreopoulos, D.G., Manuel, M.A., Saiphoo, M.M., Finer, C., Dombros, N. Lancet (1980) [Pubmed]
  40. Analysis of the pharmacokinetic interaction between cephalexin and quinapril by a nonlinear mixed-effect model. Padoin, C., Tod, M., Perret, G., Petitjean, O. Antimicrob. Agents Chemother. (1998) [Pubmed]
  41. Micellar electrokinetic capillary chromatography for the separation of cefalexin and its related substances. Li, Y.M., Zhu, Y., Vanderghinste, D., Van Schepdael, A., Roets, E., Hoogmartens, J. Electrophoresis (1999) [Pubmed]
WikiGenes - Universities