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Gene Review:

sigH - ECF RNA polymerase sigma factor SigH

Mycobacterium tuberculosis H37Rv

Fernandes, N.D. et al., Manganelli, R. et al., Kaushal, D. et al., Song, T. et al., Raman, S. et al., et al.

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Disease relevance of sigH

A defined Mycobacterium tuberculosis mutant strain lacking the sigH-encoded transcription factor showed a distinctive infection phenotype [1].
We cloned a new gene, sigH, encoding an alternative sigma factor in Streptomyces coelicolor A3(2) [2].

High impact information on sigH

In this work we show that RshA, a protein encoded by a gene in the sigH operon, is an anti-sigma factor of SigH [3].
In previously published work, we identified three Mycobacterium tuberculosis sigma (sigma) factor genes responding to heat shock (sigB, sigE and sigH) [4].
In this work we investigated the role of sigH in the M. tuberculosis response to heat and oxidative stress [5].
In comparison to the wild type, an M. smegmatis sigH mutant was found to be more susceptible to cumene hydroperoxide stress but to be similar in logarithmic growth, stationary-phase survival, and survival following several other stresses [6].

References

Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH. Kaushal, D., Schroeder, B.G., Tyagi, S., Yoshimatsu, T., Scott, C., Ko, C., Carpenter, L., Mehrotra, J., Manabe, Y.C., Fleischmann, R.D., Bishai, W.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
Identification and transcriptional characterization of the gene encoding the stress-response sigma factor sigma(H) in streptomyces coelicolor A3(2). Kormanec, J., Sevcíková, B., Halgasová, N., Knirschová, R., Rezuchová, B. FEMS Microbiol. Lett. (2000) [Pubmed]
RshA, an anti-sigma factor that regulates the activity of the mycobacterial stress response sigma factor SigH. Song, T., Dove, S.L., Lee, K.H., Husson, R.N. Mol. Microbiol. (2003) [Pubmed]
The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Manganelli, R., Voskuil, M.I., Schoolnik, G.K., Smith, I. Mol. Microbiol. (2001) [Pubmed]
The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis. Raman, S., Song, T., Puyang, X., Bardarov, S., Jacobs, W.R., Husson, R.N. J. Bacteriol. (2001) [Pubmed]
A mycobacterial extracytoplasmic sigma factor involved in survival following heat shock and oxidative stress. Fernandes, N.D., Wu, Q.L., Kong, D., Puyang, X., Garg, S., Husson, R.N. J. Bacteriol. (1999) [Pubmed]

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