Gene Review:
BH1999 - 4-hydroxybenzoyl-CoA thioesterase
Bacillus halodurans C-125
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High impact information on BH1999
- The BH1999 gene is juxtaposed with a gene cluster that contains genes believed to function in gentisate oxidative degradation [1].
- In this study, we have shown that recombinant BH1999 from Bacillus halodurans catalyzes the hydrolysis of gentisyl coenzyme A (CoA) (2,5-dihydroxybenzoyl-coenzyme A) at physiological pH with a k(cat)/K(m) of 1.6 x 10(6) M(-1) s(-1) and the hydrolysis of 3-hydroxybenzoyl-CoA with a k(cat)/K(m) of 3.0 x 10(5) M(-1) s(-1) [1].
- Gentisyl-CoA thioesterase shares the backbone fold and the use of an active site aspartate residue to mediate catalysis with the 4-hydroxybenzoyl-CoA thioesterase of the hotdog fold enzyme superfamily [1].
References
- The BH1999 protein of Bacillus halodurans C-125 is gentisyl-coenzyme A thioesterase. Zhuang, Z., Song, F., Takami, H., Dunaway-Mariano, D. J. Bacteriol. (2004) [Pubmed]
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