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Gene Review:

FMNL3 - formin-like 3

Homo sapiens

Synonyms: DKFZp762B245, FHOD3, Formin homology 2 domain-containing protein 3, Formin-like protein 3, KIAA2014, ...

Katoh, M. et al., Neumann, G.M. et al.

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Disease relevance of FMNL3

FMNL1 mRNA was expressed in natural killer cells, Burkitt lymphoma, pancreatic cancer, prostate cancer, and lung large cell carcinoma, FMNL2 mRNA in several normal tissues, diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma, and FMNL3 mRNA in gastric cancer [1].

High impact information on FMNL3

Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico [1].
The complete amino-acid sequences of WBP1A and WBP1B (determined by Edman sequencing and ESMS of proteolytically derived fragments) and N-terminal sequences of WBP2 and WBP3 are highly homologous to each other and to sequences of low molecular weight, basic plant lipid transfer proteins (LTPs) [2].

Biological context of FMNL3

FMNL1, FMNL2 and FMNL3 genes encode A and B isoforms with the C-terminal divergence due to alternative splicing (cassette splicing of exon 26) [1].

References

Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
Purification and sequencing of a family of wheat lipid transfer protein homologues phosphorylated by plant calcium-dependent protein kinase. Neumann, G.M., Condron, R., Thomas, I., Polya, G.M. Biochim. Biophys. Acta (1994) [Pubmed]

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