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Gene Review

FMNL1  -  formin-like 1

Homo sapiens

Synonyms: C17orf1, C17orf1B, CLL-associated antigen KW-13, FHOD4, FMNL, ...
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Disease relevance of FMNL1


High impact information on FMNL1

  • C17orf1, a gene expressed in skeletal muscle and heart, was initially isolated from a fetal brain cDNA library and localized centromeric to and partially within the proximal CMT1A-REP element [3].
  • Analysis of the genomic structure of C17orf1 has revealed that it contains at least six exons and spans a length of at least 17 kb [3].
  • Full exon-intron structures are presented for the NIK serine/threonine protein kinase gene and a novel gene termed C17orf1 [2].
  • Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico [4].
  • FMNL1 gene was mapped to human chromosome 17q21 [4].

Biological context of FMNL1


Anatomical context of FMNL1

  • Western blot analysis revealed expression of FMNL1 in all samples studied, although the highest expression was in T-cell NHL (P<0.05) [1].

Other interactions of FMNL1

  • We recently cloned a novel Formin-family human gene, denominated human leukocyte formin and posteriorly named as FMNL1 by the HUGO Gene Nomenclature Committee. This gene is overexpressed in lymphoid malignances and is found associated with Akt [1].


  1. High expression of FMNL1 protein in T non-Hodgkin's lymphomas. Favaro, P.M., Traina, F., Vassallo, J., Brousset, P., Delsol, G., Costa, F.F., Saad, S.T. Leuk. Res. (2006) [Pubmed]
  2. The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17. Aronsson, F.C., Magnusson, P., Andersson, B., Karsten, S.L., Shibasaki, Y., Lendon, C.L., Goate, A.M., Brookes, A.J. Hum. Genet. (1998) [Pubmed]
  3. Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat. Kennerson, M.L., Nassif, N.T., Nicholson, G.A. Genomics (1998) [Pubmed]
  4. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
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