The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

VP40  -  matrix protein

Zaire ebolavirus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of VP40

  • Using biochemical assays, it has been demonstrated that expression of Ebola virus VP40 alone in mammalian cells induced production of particles with a density similar to that of virions [1].
  • Recombinant baculoviruses (rBV) expressing Ebola virus VP40 (rBV-VP40) or GP (rBV-GP) proteins were generated [2].

High impact information on VP40

  • Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP [1].
  • VP40 induced budding from the plasma membrane of filamentous particles, which differed in length but had uniform diameters of approximately 65 nm [1].
  • These results demonstrated the central role of VP40 in formation of the filamentous structure of Ebola virions and may suggest an interaction between VP40 and GP in morphogenesis [1].
  • Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology [3].
  • Overall, these findings indicate that major changes in morphology of VP40 VLPs were likely not responsible for enhanced budding of VP40 VLPs in the presence of GP, NP and/or VP35 [3].

Anatomical context of VP40

  • Ebola encoded NP and VP35 accumulated in cytoplasmic inclusion bodies whereas VP40 was mainly membrane associated but it was also present diffusely in the cytoplasm as well as in the euchromatic areas of the nucleus [4].

Analytical, diagnostic and therapeutic context of VP40

  • To determine the morphological properties of these particles, cells expressing VP40 and the particles released from the cells were examined by electron microscopy [1].


  1. Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP. Noda, T., Sagara, H., Suzuki, E., Takada, A., Kida, H., Kawaoka, Y. J. Virol. (2002) [Pubmed]
  2. Ebola virus-like particles produced in insect cells exhibit dendritic cell stimulating activity and induce neutralizing antibodies. Ye, L., Lin, J., Sun, Y., Bennouna, S., Lo, M., Wu, Q., Bu, Z., Pulendran, B., Compans, R.W., Yang, C. Virology (2006) [Pubmed]
  3. Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology. Johnson, R.F., Bell, P., Harty, R.N. Virol. J. (2006) [Pubmed]
  4. Ebola virus infection inversely correlates with the overall expression levels of promyelocytic leukaemia (PML) protein in cultured cells. Björndal, A.S., Szekely, L., Elgh, F. BMC Microbiol. (2003) [Pubmed]
WikiGenes - Universities