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Gene Review

FAM50A  -  family with sequence similarity 50, member A

Homo sapiens

Synonyms: 9F, DXS9928E, HXC-26, HXC26, Protein FAM50A, ...
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High impact information on FAM50A

  • The XAP-5 and X5L genes are expressed in a wide range of tissues but are differentially expressed in testis [1].
  • A comparison to genomic sequence shows that XAP-5 comprises 13 exons spanning 6.5 kb [2].
  • Camphorquinone with VL irradiation increased the radical production, whereas 9F with VL irradiation increased ROS production, as well as effecting changes in the DPPC phase-transition properties [3].
  • These findings were compared with those of 9-fluorenone (9F), an aromatic photo-initiator with long conjugated groups [3].
  • The isolated cDNA, termed HXC-26, contained an open reading frame of 975 nucleotides encoding 325 amino acids (38,848 Da) [4].

Biological context of FAM50A


  1. Human and mouse XAP-5 and XAP-5-like (X5L) genes: identification of an ancient functional retroposon differentially expressed in testis. Sedlacek, Z., Münstermann, E., Dhorne-Pollet, S., Otto, C., Bock, D., Schütz, G., Poustka, A. Genomics (1999) [Pubmed]
  2. Differential expression of XAP5, a candidate disease gene. Mazzarella, R., Pengue, G., Yoon, J., Jones, J., Schlessinger, D. Genomics (1997) [Pubmed]
  3. Comparative radical production and cytotoxicity induced by camphorquinone and 9-fluorenone against human pulp fibroblasts. Atsumi, T., Ishihara, M., Kadoma, Y., Tonosaki, K., Fujisawa, S. Journal of oral rehabilitation. (2004) [Pubmed]
  4. Isolation and analysis of a novel gene, HXC-26, adjacent to the rab GDP dissociation inhibitor gene located at human chromosome Xq28 region. Toyoda, A., Sakai, T., Sugiyama, Y., Kusuda, J., Hashimoto, K., Maeda, H. DNA Res. (1996) [Pubmed]
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