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Gene Review: 

ECs5276  -  protein FimD

Escherichia coli O157:H7 str. Sakai

 
 
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Disease relevance of ECs5276

  • Adhesive type 1 pili from uropathogenic Escherichia coli are filamentous protein complexes that are attached to the assembly platform FimD in the outer membrane [1].
 

High impact information on ECs5276

  • During pilus assembly, FimD binds complexes between the chaperone FimC and type 1 pilus subunits in the periplasm and mediates subunit translocation to the cell surface [1].
  • Mutagenesis of the P pilus usher PapC and the type 1 pilus usher FimD was undertaken to elucidate the initial stages of pilus biogenesis at the OM [2].
 

Biological context of ECs5276

  • Similarly, an intact FimD N terminus was required for chaperone-subunit binding and pilus biogenesis [2].

References

  1. Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD. Nishiyama, M., Horst, R., Eidam, O., Herrmann, T., Ignatov, O., Vetsch, M., Bettendorff, P., Jelesarov, I., Grütter, M.G., Wüthrich, K., Glockshuber, R., Capitani, G. EMBO J. (2005) [Pubmed]
  2. The usher N terminus is the initial targeting site for chaperone-subunit complexes and participates in subsequent pilus biogenesis events. Ng, T.W., Akman, L., Osisami, M., Thanassi, D.G. J. Bacteriol. (2004) [Pubmed]
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