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Gene Review:

ECs0451 - branched-chain amino acid ABC transporter...

Escherichia coli O157:H7 str. Sakai

Wood, J.M., Quay, S.C. et al., Anderson, J.J. et al., Landick, R. et al.

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Disease relevance of ECs0451

Leucine is transported into E coli by two osmotic shock-sensitive, high-affinity systems (LIV-I and leucine-specific systems) and one membrane bound, low-affinity system (LIV-II) [1].

High impact information on ECs0451

The L-leucine, L-iosleucine, and L-valine transport activity in membrane vesicles from strain ML 308-225 has the properties of system LIV-II [2].
In addition to the previously characterized osmotic shock-sensitive LS (L-leucine-specific) and LIV-I (L-leucine; L-isoleucine-, and L-valine-specific) activities, a third system (designated LIV-II) has been detected, confirming a report by Rahmanian et al [2].
Strains of the genotype livH+ livP were found to have normal high-affinity binding protein-mediated transport (LIV-I and leucine specific), whereas the low-affinity (LIV-II) transport was completely missing [3].
0. Kinetics of leucine transport showed that the LIV (leucine, isoleucine, and valine)-I (binding protein-associated) transport system is increased 8.5-fold, whereas the LIV-II (membrane-bound) system is increased 1.5-fold in the rho mutant under leucine-limited growth conditions [4].

References

Regulation of high-affinity leucine transport in Escherichia coli. Landick, R., Anderson, J.J., Mayo, M.M., Gunsalus, R.P., Mavromara, P., Daniels, C.J., Oxender, D.L. J. Supramol. Struct. (1980) [Pubmed]
Leucine transport in Escherichia coli. The resolution of multiple transport systems and their coupling to metabolic energy. Wood, J.M. J. Biol. Chem. (1975) [Pubmed]
Genetic separation of high- and low-affinity transport systems for branched-chain amino acids in Escherichia coli K-12. Anderson, J.J., Oxender, D.L. J. Bacteriol. (1978) [Pubmed]
Regulation of amino acid transport in Escherichia coli by transcription termination factor rho. Quay, S.C., Oxender, D.L. J. Bacteriol. (1977) [Pubmed]

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