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Gene Review

oxyS  -  miscRNA

Escherichia coli O157:H7 str. Sakai

 
 
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Disease relevance of oxyS

  • Exposure of E. coli to hydrogen peroxide induces the transcription of a small RNA denoted oxyS [1].
 

High impact information on oxyS

  • The oxyS RNA is stable, abundant, and does not encode a protein. oxyS activates and represses the expression of numerous genes in E. coli, and eight targets, including genes encoding the transcriptional regulators FhlA and sigma(S), were identified. oxyS expression also leads to a reduction in spontaneous and chemically-induced mutagenesis [1].
  • Probably the BtuB is negatively regulated by a global regulator, oxyS, induced during oxidative stress [2].
 

Analytical, diagnostic and therapeutic context of oxyS

  • Our RT-PCR analysis revealed an elevation of expression of the oxyS gene in the lon mutant [2].

References

  1. A small, stable RNA induced by oxidative stress: role as a pleiotropic regulator and antimutator. Altuvia, S., Weinstein-Fischer, D., Zhang, A., Postow, L., Storz, G. Cell (1997) [Pubmed]
  2. An E. coli lon mutant conferring partial resistance to colicin may reveal a novel role in regulating proteins involved in the translocation of colicin. Lee, Y.Y., Hu, H.T., Liang, P.H., Chak, K.F. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
 
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