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Gene Review

ECs4605  -  sensory histidine kinase UhpB

Escherichia coli O157:H7 str. Sakai

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Disease relevance of ECs4605

  • Expression of the Escherichia coli sugar phosphate transporter UhpT is induced by extracellular glucose 6-phosphate through a transmembrane signaling process dependent on the sensor kinase UhpB and the UhpT homolog, UhpC [1].

High impact information on ECs4605

  • Signaling is initiated through sensing of extracellular glucose 6-phosphate by membrane-bound UhpC, which in turn modulates the histidine-protein kinase UhpB [2].
  • The phosphoryl transfer domain of UhpB interacts with the response regulator UhpA [3].
  • This region of UhpB is related to the phosphoryl transfer domain of EnvZ, which forms half of an interdimer four-helix bundle and is responsible for dimerization of its cytoplasmic domain [3].
  • The interference phenotype shown by UhpB in excess of UhpC appears to include the binding and sequestration of UhpA [4].
  • Variant forms of UhpB which were active in the absence of UhpC carried amino acid substitutions near motifs conserved in HK proteins [4].

Chemical compound and disease context of ECs4605


Biological context of ECs4605

  • The C-terminal portion of UhpB displayed matches to the corresponding portions of another family of proteins (EnvZ, PhoMR, NtrB, and DctB) that participate in regulation of gene expression in response to environmental factors [5].


  1. Protein phosphorylation affects binding of the Escherichia coli transcription activator UhpA to the uhpT promoter. Dahl, J.L., Wei, B.Y., Kadner, R.J. J. Biol. Chem. (1997) [Pubmed]
  2. Cooperativity in signal transfer through the Uhp system of Escherichia coli. Verhamme, D.T., Postma, P.W., Crielaard, W., Hellingwerf, K.J. J. Bacteriol. (2002) [Pubmed]
  3. The phosphoryl transfer domain of UhpB interacts with the response regulator UhpA. Wright, J.S., Kadner, R.J. J. Bacteriol. (2001) [Pubmed]
  4. The histidine kinase domain of UhpB inhibits UhpA action at the Escherichia coli uhpT promoter. Wright, J.S., Olekhnovich, I.N., Touchie, G., Kadner, R.J. J. Bacteriol. (2000) [Pubmed]
  5. Role of uhp genes in expression of the Escherichia coli sugar-phosphate transport system. Weston, L.A., Kadner, R.J. J. Bacteriol. (1988) [Pubmed]
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