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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DGKI  -  diacylglycerol kinase, iota

Homo sapiens

Synonyms: DAG kinase iota, DGK-IOTA, DGK-iota, Diacylglycerol kinase iota, Diglyceride kinase iota
 
 
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High impact information on DGKI

  • The gene encoding DGKiota was localized to human chromosome 7q32.3-33, which is known to be a locus for an inherited form of retinitis pigmentosa [1].
  • In the early phase of 90 min of middle cerebral artery occlusion, DGKzeta-immunoreactivity is reduced rapidly in the nucleus of cortical neurons in the ischemic core, while DGKiota and other neuronal proteins such as MAP-2 and NeuN remain intact [2].
  • Double-immunofluorescent imaging of these isozymes showed that they coexisted in a large population of DRG neurons at distinct subcellular sites, i.e., DGKzeta in the nucleus and DGKiota in the cytoplasm [3].
 

Analytical, diagnostic and therapeutic context of DGKI

  • In cells transfected with the DGKiota cDNA, we detected an approximately 130-kDa protein by immunoassay, and activity assays demonstrated that it encodes a functional DAG kinase [1].

References

  1. The cloning and characterization of a novel human diacylglycerol kinase, DGKiota. Ding, L., Traer, E., McIntyre, T.M., Zimmerman, G.A., Prescott, S.M. J. Biol. Chem. (1998) [Pubmed]
  2. Diacylglycerol kinase zeta is involved in the process of cerebral infarction. Nakano, T., Hozumi, Y., Ali, H., Saino-Saito, S., Kamii, H., Sato, S., Kayama, T., Watanabe, M., Kondo, H., Goto, K. Eur. J. Neurosci. (2006) [Pubmed]
  3. Gene expression and localization of diacylglycerol kinase isozymes in the rat spinal cord and dorsal root ganglia. Sasaki, H., Hozumi, Y., Hasegawa, H., Ito, T., Takagi, M., Ogino, T., Watanabe, M., Goto, K. Cell Tissue Res. (2006) [Pubmed]
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